Porphyromonas gingivalis infection increases osteoclastic bone resorption and osteoblastic bone formation in a periodontitis mouse model

W Zhang, J Ju, T Rigney, G Tribble - BMC Oral Health, 2014 - Springer
Background Porphyromonas gingivalis has been shown to invade osteoblasts and inhibit
their differentiation and mineralization in vitro. However, it is unclear if P. gingivalis can …

The role of cytokines in a Porphyromonas gingivalis‐induced murine abscess model

J Alayan, E Gemmell, P Ford, S Hamlet… - Oral microbiology …, 2007 - Wiley Online Library
Introduction: Porphyromonas gingivalis is an important periodontopathic bacterium that is
strongly associated with periodontal disease and is part of human dental plaque …

Porphyromonas gingivalis traffics into endoplasmic reticulum-rich-autophagosomes for successful survival in human gingival epithelial cells

K Lee, JAS Roberts, CH Choi, KR Atanasova, Ö Yilmaz - Virulence, 2018 - Taylor & Francis
Porphyromonas gingivalis, an opportunistic pathogen usurps gingival epithelial cells (GECs)
as primary intracellular niche for its colonization in the oral mucosa. However, the precise …

Porphyromonas gingivalis downregulates the immune response of fibroblasts

E Palm, H Khalaf, T Bengtsson - BMC microbiology, 2013 - Springer
Background Porphyromonas gingivalis is a key pathogen in periodontitis, an inflammatory
disease leading to destruction of bone and tooth-supporting tissue. P. gingivalis possesses …

Advances in periodontal pathogens

IG Sufaru, MA Martu, SM Solomon - Microorganisms, 2022 - mdpi.com
Even though periodontitis is considered an infectious disease, there are a number of factors
that distinguish it from other infectious diseases: it is not the result of infection with an …

Porphyromonas gingivalis diffusible signaling molecules enhance Fusobacterium nucleatum biofilm formation via gene expression modulation

Y Yamaguchi-Kuroda, Y Kikuchi, E Kokubu… - Journal of Oral …, 2023 - Taylor & Francis
Background Periodontitis is caused by a dysbiotic shift in the dental plaque microbiome.
Fusobacterium nucleatum is involved in the colonization of Porphyromonas gingivalis, which …

Porphyromonas gingivalis-Epithelial Cell Interactions in Periodontitis

E Andrian, D Grenier… - Journal of dental …, 2006 - journals.sagepub.com
Emerging data on the consequences of the interactions between invasive oral bacteria and
host cells have provided new insights into the pathogenesis of periodontal disease. Indeed …

Mechanisms of Porphyromonas gingivalis to translocate over the oral mucosa and other tissue barriers

CA de Jongh, TJ de Vries, FJ Bikker… - Journal of Oral …, 2023 - Taylor & Francis
ABSTRACT Introduction The oral pathogen Porphyromonas gingivalis is not only associated
with periodontitis but also with systemic diseases elsewhere in the body. The mechanisms …

Evaluation of the host response in various models of induced periodontal disease in mice

RS de Molon, ED de Avila… - Journal of …, 2014 - Wiley Online Library
Background: The aim of this study is to characterize and evaluate the host response caused
by three different models of experimental periodontitis in mice. Methods: C57BL/6 wild‐type …

Prospects for treatment of Porphyromonas gingivalis-mediated disease – immune-based therapy

EC Reynolds, N O'Brien-Simpson, T Rowe… - Journal of oral …, 2015 - Taylor & Francis
Chronic periodontitis is an inflammatory disease of the supporting tissues of the teeth
associated with a polymicrobial biofilm (subgingival plaque) accreted to the tooth which …