Itaconate is an immunomodulatory metabolite produced by immune cells under microbial
stimulation and certain pro-inflammatory conditions and triggers antioxidant and anti …

Metabolic products can lead to crucial biological function alterations. Itaconate is probably
the best example of how a metabolic process can be diverted to generate an …

Macrophages play a central role in innate immunity as the first line of defense against
pathogen infection. Upon exposure to inflammatory stimuli, macrophages rapidly respond …

Itaconate is a newly discovered mammalian metabolite bearing significant implications for
our understanding of cellular immunometabolism and antimicrobial defense. Here, we …

The field of immunometabolism has demonstrated that metabolites can lead double lives as
immunomodulators. Itaconate is perhaps the best example of such a moonlighting molecule …

With advances in immunometabolic studies, more and more evidence has shown that
metabolic changes profoundly affect the immune function of macrophages. The tricarboxylic …

The metabolite itaconate (ITA) and its derivatives, both chemically synthesized and
endogenous, have emerged as immunoregulators, with roles in limiting inflammation but …

Endogenous small molecules are metabolic regulators of cell function. Itaconate is a key
molecule that accumulates in cells when the Krebs cycle is disrupted. Itaconate is derived …

Macrophages exposed to inflammatory stimuli including LPS undergo metabolic
reprogramming to facilitate macrophage effector function. This metabolic reprogramming …

Metabolites have recently been found to be involved in significant biological regulation and
changes. Itaconate, an important intermediate metabolite isolated from the tricarboxylic acid …