Expression of exosomal microRNAs during chondrogenic differentiation of human bone mesenchymal stem cells

H Sun, S Hu, Z Zhang, J Lun, W Liao… - Journal of cellular …, 2019 - Wiley Online Library
The aim of the current study was to compare the expression of microRNAs (miRNAs) in
exosomes derived from human bone mesenchymal stem cells (hBMSCs) with and without …

Altered microRNA expression profile in exosomes during osteogenic differentiation of human bone marrow-derived mesenchymal stem cells

JF Xu, G Yang, XH Pan, SJ Zhang, C Zhao, BS Qiu… - PloS one, 2014 - journals.plos.org
The physiological role of microRNAs (miRNAs) in osteoblast differentiation remains elusive.
Exosomal miRNAs isolated from human bone marrow-derived mesenchymal stem cells …

Mesenchymal stem cell-derived exosomes have altered microRNA profiles and induce osteogenic differentiation depending on the stage of differentiation

X Wang, O Omar, F Vazirisani, P Thomsen, K Ekström - PloS one, 2018 - journals.plos.org
Human mesenchymal stem cell (hMSC)-derived exosomes have shown regenerative
effects, but their role in osteogenesis and the underlying mechanism are yet to be …

State of the art: the immunomodulatory role of MSCs for osteoarthritis

DG Kwon, MK Kim, YS Jeon, YC Nam, JS Park… - International journal of …, 2022 - mdpi.com
Osteoarthritis (OA) has generally been introduced as a degenerative disease; however, it
has recently been understood as a low-grade chronic inflammatory process that could …

Mesenchymal stem cell-derived exosomes and MicroRNAs in cartilage regeneration: biogenesis, efficacy, miRNA enrichment and delivery

JB Foo, QH Looi, CW How, SH Lee, ME Al-Masawa… - Pharmaceuticals, 2021 - mdpi.com
Exosomes are the small extracellular vesicles secreted by cells for intercellular
communication. Exosomes are rich in therapeutic cargos such as microRNA (miRNA), long …

Exosomes derived from miR-126-3p-overexpressing synovial fibroblasts suppress chondrocyte inflammation and cartilage degradation in a rat model of osteoarthritis

Y Zhou, J Ming, Y Li, B Li, M Deng, Y Ma, Z Chen… - Cell Death …, 2021 - nature.com
MicroRNAs (miRNAs) encapsulated within exosomes can serve as essential regulators of
intercellular communication and represent promising biomarkers of several aging …

Exosomes derived from bone marrow mesenchymal stem cells pretreated with decellularized extracellular matrix enhance the alleviation of osteoarthritis through miR …

Y Zhang, G Qi, Y Yan, C Wang, Z Wang… - The Journal of Gene …, 2023 - Wiley Online Library
Background Osteoarthritis (OA) is a prevalent degenerative articular disease for which there
is no effective treatment. Progress has been made in mesenchymal stem cell (MSC)‐based …

[HTML][HTML] Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent …

SC Tao, T Yuan, YL Zhang, WJ Yin, SC Guo… - Theranostics, 2017 - ncbi.nlm.nih.gov
OBJECTIVES: Osteoarthritis (OA) is the most common joint disease throughout the world.
Exosomes derived from miR-140-5p-overexpressing synovial mesenchymal stem cells …

The role and mechanism of exosomes from umbilical cord mesenchymal stem cells in inducing osteogenesis and preventing osteoporosis

G Yahao, W Xinjia - Cell Transplantation, 2021 - journals.sagepub.com
Mesenchymal stem cell (MSC) exosomes promote tissue regeneration and repair, and thus
might be used to treat many diseases; however, the influence of microenvironmental …

The roles of bone‐derived exosomes and exosomal micro RNA s in regulating bone remodelling

Y Xie, Y Chen, L Zhang, W Ge… - Journal of cellular and …, 2017 - Wiley Online Library
Pathological destructive bone diseases are primarily caused by the failure of a lifelong self‐
renewal process of the skeletal system called bone remodelling. The mechanisms …