The functional activity of deoxyadenosine 5′(α‐thio) triphosphate (dATPαS) was assessed
at the cloned human P2Y1 receptor stably expressed in 1321N1 human astrocytoma cells …

The agonist selectivity for adenosine di-and triphosphates was determined for the human
P2Y1 receptor stably expressed in human 1321N1 astrocytoma cells and was studied under …

We conducted a mutational analysis of residues potentially involved in the adenine
nucleotide binding pocket of the human P2Y1receptor. Mutated receptors were expressed in …

Although P2 receptors mediate a myriad of physiological effects of extracellular adenine
nucleotides, study of this broad class of receptors has been compromised by a lack of P2 …

A recently cloned G protein-coupled receptor (named the p2y7 receptor) with relatively low
sequence identity to previously cloned P2Y receptors was proposed to be a member of this …

Analysis of the P2Y family of nucleotide‐activated G‐protein‐coupled receptors has been
compromised by the lack of selective high‐affinity, high‐specific‐radioactivity radioligands …

Site‐directed mutagenesis was used to search for amino acid residues of the human P2Y1
receptor involved in the binding of the P2 receptor antagonists pyridoxal‐5′‐phosphate‐6 …

An orphan G protein-coupled receptor, termed 6H1, with∼ 30% sequence identity to P2Y
receptors has been proposed to be a P2Y receptor (p2y5) based solely on a radioligand …

The effect of 2, 2′-pyridylisatogen tosylate (PIT) on the human P2Y1 receptor and on other
recombinant P2Y receptors has been studied. We first examined the modulation by PIT of …

The equal potency and efficacy of the agonists, ATP and UTP, pharmacologically distinguish
the P2Y 2 receptor from other nucleotide receptors. Investigation of the desensitization of the …