The liver plays a major role in modifying the total circulating hormone concentrations of
thyroxine and triiodo-thyronme by secretion and degradation of carrier proteins. It also is a …

Thyroid hormone synthesis and secretion is regulated by a classic feedback loop system.
The hypothalamus, through the release of thyrotropinreleasing hormone (TRH), stimulates …

The liver is the major site of the peripheral metabolism of thyroid hormones and is involved
in conjugation, biliary execretion, oxidative deamination, and extrathyroidal deiodination of …

Close relationships exist between the liver and the thyroid. The liver is important in the
transport, metabolism, storage and excretion of thyroid hormones as well as being an …

The liver plays a dominant role in the metabolism of the thyroidal hormones; it is here that
the 5'deiodase acts to convert part of T4 to T3. There are eight further circulating …

Thyroxine and tri‐iodothyronine are essential for normal organ growth, development and
function. These hormones regulate the basal metabolic rate of all cells, including …

Possible arterio-venous gradients of T4, T3, rT3 and 3, 3′-diiodothyronine (3, 3′-T2)
across the liver and the kidneys were measured in 9 patients with varying degrees of liver …

We studied serum concentrations of thyroid hormones and thyrotropin (TSH) in 23 clinically
euthyroid patients with hepatic cirrhosis. The mean serum total thyroxine T4 concentration of …

Various aspects of the effect of liver damage on thyroid function were studied in 35 cases of
liver disease (with 30 normal controls) and in a group of thyroidectomized rats made toxic …

The gastrointestinal tract interacts actively with the thyroid hormones, T4 and T3. Both T4
and T3 are absorbed well but incompletely from the gut, and many factors affect this …