In this study, we investigated the mechanism by which UVB irradiation activates Akt (also
known as protein kinase B (PKB)) in mouse epidermal JB6 cells. Treatment with a …

Mitogen activated protein (MAP) kinase belongs to a large family of serine/threonine protein
kinases, including extracellular-signal-regulated protein kinases (Erks), P38 kinase and c …

Mitogen-and stress-activated protein kinases, MSK1 and the closely related isoform MSK2,
are nuclear kinases that are activated following mitogen stimulation or cellular stress …

The exposure of mammalian cells to UV irradiation leads to the activation of transcription
factors and protein kinases, which are believed to be responsible for the carcinogenic effects …

Ultraviolet (UV) irradiation stimulates stress-activated protein kinase/c-Jun N-terminal kinase
(SAPK/JNK), which is a member of the mitogen-activated protein kinase (MAPK) superfamily …

MAPK phosphatase-1 (DUSP1/MKP-1) is a mitogen and stress-inducible dual specificity
protein phosphatase, which can inactivate all three major classes of MAPK in mammalian …

Previous studies have demonstrated that AKT1 and AKT3 are activated by heat shock and
oxidative stress via both phosphatidylinositol 3-kinase-dependent and-independent …

UV-induced signal transduction may be involved in tumor promotion and induction of
apoptosis. The role of protein kinase C (PKC) in UVB-induced signal transduction is not well …

Ultraviolet (UV) irradiation induces various cellular responses by activating many UV-
responsive enzymes including mitogen-activated protein kinases (MAPKs). Various G …

Background The exposure of skin keratinocytes to Ultraviolet (UV) irradiation leads to Akt
phosphorylation at Ser-473, which is important for the carcinogenic effects of excessive sun …