Immune molecules have been discovered recently to play critical roles in the development,
function, and plasticity of the cerebral cortex. MHC class I (MHCI) molecules are expressed …

Background Several recent studies have highlighted the important role of immunity-related
molecules in synaptic plasticity processes in the developing and adult mammalian brains. It …

Proteins of the major histocompatibility complex class I (MHCI) are known for their role in the
vertebrate adaptive immune response, and are required for normal postnatal brain …

Members of the major histocompatibility complex (MHC) class I family of proteins are well
known for their central role in the adaptive immune system, where they present self and non …

Several recent studies suggested a role for neuronal major histocompatibility complex class
I (MHCI) molecules in certain forms of synaptic plasticity in the hippocampus of rodents …

Until recently, neurons in the healthy brain were considered immune-privileged because
they did not appear to express MHC class I (MHCI). However, MHCI mRNA was found to be …

Synapse pruning is an activity-regulated process needed for proper circuit sculpting in the
developing brain. Major histocompatibility class I (MHCI) molecules are regulated by activity …

Class I major histocompatibility complex (class I MHC) molecules, known to be important for
immune responses to antigen, are expressed also by neurons that undergo activity …

Major histocompatibility complex class I (MHCI) molecules modulate activity-dependent
refinement and plasticity. We found that MHCI also negatively regulates the density and …

Research has long supported the view that the brain is immunologically privileged, in part
because normal, uninfected neurons were not thought to express major histocompatibility …