Radiotherapy of cancer has been traditionally considered as a local therapy without
noticeable effects outside the irradiated fields. However, ionizing radiation exerts multiple …

Radiotherapy (RT) is a highly effective anticancer treatment that is delivered to more than
half of all patients with cancer. In addition to the well-documented direct cytotoxic effects, RT …

Although cancer progression is primarily driven by the expansion of tumor cells, the tumor
microenvironment and anti-tumor immunity also play important roles. Herein, we consider …

Radiotherapy, primarily known for its cytotoxic effect on the tumor cells, via the induction of
DNA damages, has the ability to induce a systemic antitumoral response. By an …

Radiotherapy has been used for more than a hundred years as a local tumor treatment. The
occurrence of systemic antitumor effects manifesting as regression of tumors outside of the …

Radiotherapy (RT) is currently used in more than 50% of cancer patients during the course
of their disease in the curative, adjuvant or palliative setting. RT achieves good local control …

Radiotherapy applies ionizing irradiation to selected areas of the body with the scope of
destroying cancer cells, either as part of curative therapies to remove a primary malignant …

In the era of cancer immunotherapy, there is significant interest in combining conventional
cancer therapies, such as radiotherapy, with drugs that stimulate the immune system. The …

Cancer immunotherapy exploits the immune system's ability to differentiate between tumor
target cells and host cells. Except for limited success against a few tumor types, most …

Besides its direct cytotoxic effect on the tumor cells, radiation therapy is also able to elicit an
immune-mediated systemic anti-tumor response, resulting in tumor regression in irradiated …