Highlights•Exercise has systemic lipid lowering effects.•Exercise training results in a
remodeling of skeletal muscle lipid metabolism.•Storage of lipids in LDs and oxidative …

Skeletal muscle is one of the main regulators of carbohydrate and lipid metabolism in our
organism, and therefore, it is highly susceptible to changes in glucose and fatty acid (FA) …

Fatty acids are an important energy source during exercise. Training status and substrate
availability are determinants of the relative and absolute contribution of fatty acids and …

Lipids are an important fuel for submaximal aerobic exercise. The ways in which lipid
oxidation is regulated during locomotion is an area of active investigation. Indeed, the …

The incidence of obesity and metabolic disease, such as type 2 diabetes mellitus (T2D), is
rising globally. Dietary lipid over supply leads to lipid accumulation at ectopic sites, such as …

Purpose Smaller lipid droplet morphology and GLUT 4 protein expression have been
associated with greater muscle oxidative capacity and glucose uptake, respectively. The …

Intramuscular accumulation of triacylglycerol, in the form of lipid droplets (LD), has gained
widespread attention as a hallmark of metabolic disease and insulin resistance …

The increased prevalence of hyperlipidemia, hypertriglyceridemia, hypercholesterolemia,
and fatty liver disease has provided increasingly negative connotations toward lipids …

The majority of fat in the human body is stored as triacylglycerols in white adipose tissue. In
the obese state, adipose tissue mass expands and excess lipids are stored in non-adipose …

Lipolysis involves the sequential breakdown of fatty acids from triacylglycerol and is
increased during energy stress such as exercise. Adipose triglyceride lipase (ATGL) is a key …