DNA methylation is an epigenetic mark that is essential for the development of mammals; it
is frequently altered in diseases ranging from cancer to psychiatric disorders. The presence …

ABSTRACT DNA methylation is an epigenetically inherited chemical modification that is
associated with transcriptional silencing and is essential for mammalian development. The …

Methylated DNA can be specifically recognized by a set of proteins called methyl-CpG-
binding proteins (MBPs), which belong to three different structural families in mammals: the …

Background DNA methylation is an epigenetic modification that plays a crucial role in a
variety of biological processes. Methylated DNA is specifically bound by Methyl-CpG …

Methyl-CpG Binding Domain (MBD) proteins are thought to be key molecules in the
interpretation of DNA methylation signals leading to gene silencing through recruitment of …

Covalent modification of DNA via deposition of a methyl group at the 5′ position on
cytosine residues alters the chemical groups available for interaction in the major groove of …

Recent technological advances have made it possible to decode DNA methylomes at single-
base-pair resolution under various physiological conditions. Many aberrant or differentially …

In vertebrates, densely methylated DNA is associated with inactive transcription. Actors in
this process include proteins of the MBD family that can recognize methylated CpGs and …

MBD1, a member of the methyl-CpG-binding domain family of proteins, has been reported to
repress transcription of methylated and unmethylated promoters. As some MBD1 isoforms …

Methyl-CpG binding proteins play an essential role in translating DNA methylation marks
into a downstream transcriptional response, which has implications for both normal cell …