Islet neogenesis, or the differentiation of islet cells from precursor cells, is seen in vitro and in
vivo both embryonically and after birth. However, little is known about the differentiation …

The mechanism of islet neogenesis remains poorly understood, despite its potential
applications in regenerative or replacement therapies for the treatment of insulin-dependent …

Objective: Despite great progress in understanding the transcriptional regulation of the
development of insulin-secreting β cells, the quantitative temporal expression of insulin …

Studies of islet neogenesis have suggested that the regeneration of islet cells can be
achieved through redifferentiation of pre-existing islet cells. However, this hypothesis is …

Background In both humans and rodents, glucose homeostasis is controlled by micro-
organs called islets of Langerhans composed of beta cells, associated with other endocrine …

Reliance on rodents for understanding pancreatic genetics, development and islet function
could limit progress in developing interventions for human diseases such as diabetes …

Aims/hypothesis The neogenesis of islets from cultured human adult pancreatic tissue has
been reported. The islet progenitors have been thought to be ductal cells. Since previous …

Cultured human islets can be dedifferentiated to duct-like structures composed mainly of
cytokeratin+ and nestin+ cells. Given that these structures possess the potential to …

Pancreatic islets play an essential role in regulating blood glucose level. Although the
molecular pathways underlying islet cell differentiation are beginning to be resolved, the …

Over the last years, there has been great success in driving stem cells toward insulin-
expressing cells. However, the protocols developed to date have some limitations, such as …