The role of glucagon-like peptide-1 receptor agonists (GLP-1 RA) in diabetes-related neurodegenerative diseases

D Cheng, S Yang, X Zhao, G Wang - Drug design, development …, 2023 - Taylor & Francis
Recent clinical guidelines have emphasized the importance of screening for cognitive
impairment in older adults with diabetes, however, there is still a lack of understanding about …

[HTML][HTML] The neuroprotective effects of glucagon-like peptide 1 in Alzheimer's and Parkinson's disease: An in-depth review

N Reich, C Hölscher - Frontiers in neuroscience, 2022 - frontiersin.org
Currently, there is no disease-modifying treatment available for Alzheimer's and Parkinson's
disease (AD and PD) and that includes the highly controversial approval of the Aβ-targeting …

Alternative role of glucagon-like Peptide-1 receptor agonists in neurodegenerative diseases

SD Chen, YC Chuang, TK Lin, JL Yang - European journal of …, 2023 - Elsevier
Aging is a crucial risk factor for common neurodegenerative diseases, such as Alzheimer's
disease (AD) and Parkinson's disease (PD). Limited options are available for the treatment …

[HTML][HTML] Potential role of glucagon-like peptide-1 receptor agonists in the treatment of cognitive decline and dementia in diabetes mellitus

MC Pelle, I Zaffina, F Giofrè, R Pujia… - International Journal of …, 2023 - mdpi.com
Dementia is a permanent illness characterized by mental instability, memory loss, and
cognitive decline. Many studies have demonstrated an association between diabetes and …

[HTML][HTML] Glucagon-like peptide-1: a focus on neurodegenerative diseases

M Grieco, A Giorgi, MC Gentile, M d'Erme… - Frontiers in …, 2019 - frontiersin.org
Diabetes mellitus is one of the major risk factors for cognitive dysfunction. The pathogenesis
of brain impairment caused by chronic hyperglycemia is complex and includes …

Novel GLP-1 (glucagon-like peptide-1) analogues and insulin in the treatment for Alzheimer's disease and other neurodegenerative diseases

V Calsolaro, P Edison - CNS drugs, 2015 - Springer
The link between diabetes mellitus and Alzheimer's disease (AD) has been known for the
last few decades. Since insulin and insulin receptors are known to be present in the brain …

Glucagon‐like peptide‐1, diabetes, and cognitive decline: possible pathophysiological links and therapeutic opportunities

E Mossello, E Ballini, M Boncinelli… - Journal of Diabetes …, 2011 - Wiley Online Library
Metabolic and neurodegenerative disorders have a growing prevalence in Western
countries. Available epidemiologic and neurobiological evidences support the existence of a …

[HTML][HTML] The mechanism and efficacy of GLP-1 receptor agonists in the treatment of Alzheimer's disease

H Du, X Meng, Y Yao, J Xu - Frontiers in Endocrinology, 2022 - frontiersin.org
Since type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimer's disease (AD) and both
have the same pathogenesis (eg, insulin resistance), drugs used to treat T2DM have been …

Potential role of glucagon-like peptide-1 (GLP-1) in neuroprotection

C Hölscher - CNS drugs, 2012 - Springer
The current understanding of neurodegenerative processes in sporadic diseases such as
Alzheimer's disease (AD), Parkinson's disease (PD) or multiple sclerosis is very limited …

Neuroprotective actions of glucagon-like peptide-1 (GLP-1) analogues in Alzheimer's and Parkinson's diseases

AF Batista, V Bodart-Santos, FG De Felice, ST Ferreira - CNS drugs, 2019 - Springer
The current absence of effective treatments for Alzheimer's disease (AD) and Parkinson's
disease (PD) reflects an incomplete knowledge of the underlying disease processes …