Abstract We synthesized (Z)-5-(2, 4-dihydroxybenzylidene) thiazolidine-2, 4-dione
(MHY498) as a potential tyrosinase inhibitor. MHY498 potently inhibited mushroom …

BACKGROUND: We synthesized (2RS, 4R)-2-(2, 4-dihydroxyphenyl) thiazolidine-4-
carboxylic acid (MHY384) as a potential tyrosinase inhibitor and investigated its …

As part of our continuous search for novel tyrosinase inhibitors, we designed 5, 6-
dihydroimindazo [2, 1-b] thiazol-3 (2H)-one (DHIT) derivatives based on the structure of …

Tyrosinase is a key enzyme that catalyses the initial rate‐limiting steps of melanin synthesis.
Due to its critical role in melanogenesis, various attempts were made to find potent …

We describe the design, synthesis, and biological activities of 5-chloro-2-(substituted
phenyl) benzo [d] thiazole derivatives as novel tyrosinase inhibitors. Among them, 4-(5 …

Herein we describe the design, synthesis and biological activities of 2-(substituted phenyl)
thiazolidine-4-carboxylic acid derivatives as novel tyrosinase inhibitors. The target …

The rate-determining role of tyrosinase makes it a critical component in the mechanism that
is responsible for melanogenesis. Thirteen (Z)-5-(substituted benzylidene)-3-phenyl-2 …

In this study, we designed and synthesized eight thiophene chalcone derivatives (1a–h) as
tyrosinase inhibitors and evaluated their mushroom tyrosinase inhibitory activities. Of these …

In this study, we have synthesized and studied de novo tyrosinase inhibitor, MHY1556,
which showed significantly better efficacy than other pre-existing tyrosinase inhibitors in vitro …

We attempted to design and synthesize (E)-N-substituted benzylidene-hydroxy or methoxy-
aniline derivatives and to evaluate their inhibitory effect on tyrosinase activity and anti …