Transplant recipients receive potent immunosuppressive drugs in order to prevent graft
rejection. Therapeutic drug monitoring is the current approach to guide the dosing of …

Advances in the management of patients after solid organ transplantation have led to
dramatic decreases in rates of acute rejection, but long-term graft and patient survival have …

Cyclosporine, tacrolimus, sirolimus, and mycophenolate mofetil are the primary
immunosuppressants used on pediatric organ transplantation. Therapeutic drug monitoring …

Introduction: Immunosuppressive drugs have a narrow therapeutic range and large inter-
individual response variability. This has prompted pharmacogenetic studies, mostly with …

Immunosuppressant drugs (ISDs) are routinely used in clinical practice to maintain organ
transplant survival. However, these drugs are characterized by a restricted therapeutic …

The immunosuppressive drugs used in solid-organ transplantation are potent and toxic
agents with narrow therapeutic ranges. Underdosing is associated with immunological …

Renal transplantation is the optimal form of renal replacement therapy (RRT) for the majority
of patients. Both short-and long-term graft rejection are well recognized complications …

Tailoring of immunosuppressive drug therapy to the specific requirements of the individual
patient to optimize efficacy and minimize toxicity remains one of the biggest challenges in …

Kidney transplantation is the preferred therapeutic option for end-stage kidney disease, but,
despite major therapeutic advancements, allograft rejection continues to endanger graft …

Kidney transplantation in pediatric patients has become a successful and routine procedure,
with overall 1-year patient and graft survival rates exceeding 95%. These success rates …