Candidate methylated genes in osteoarthritis explored by bioinformatics analysis

J Liu, Y Hao, Y Wang, S Hu, K Xu, C Lu - The Knee, 2016 - Elsevier
Background This study aimed to explore potential novel genes correlated with osteoarthritis
(OA). Methods The gene expression profile of GSE48422 was downloaded from the Gene …

Identification of abnormally methylated–differentially expressed genes and pathways in osteoarthritis: a comprehensive bioinformatic study

L Zheng, W Chen, G Xian, B Pan, Y Ye, M Gu… - Clinical …, 2021 - Springer
Objectives To investigate abnormally methylated–differentially expressed genes (DEGs) and
their related pathways in osteoarthritis (OA) by comprehensive bioinformatic analysis …

Identification of DNA hydroxymethylation associated genes in osteoarthritis by combined analysis of hydroxymethylation and gene expression

J Chen, Z Hong, Y Hong, X He, Q Bi, C Zhao - Journal of Orthopaedic …, 2020 - Elsevier
Background Our study aimed to explore more mechanistic insights into the epigenetic
regulation of osteoarthritis (OA). Methods The expression profiles (accession number …

Analysis of methylation datasets identified significantly changed genes and functional pathways in osteoarthritis

B Han, Z Zheng, J Ren, W Qiu, X Li - Clinical Rheumatology, 2019 - Springer
Background Researches indicate that epigenetics was involved in osteoarthritis (OA). The
purpose of this study was to describe the alterations of DNA methylation in hip and knee OA …

[HTML][HTML] Analysis of mRNA expression and DNA methylation datasets according to the genomic distribution of CpG sites in osteoarthritis

P Yi, X Xu, J Yao, B Qiu - Frontiers in Genetics, 2021 - frontiersin.org
Objectives Transcriptional changes in cartilage can impact function by causing degradation
such as that which occurs during the development of osteoarthritis (OA). Epigenetic …

[HTML][HTML] Combined bioinformatics analysis reveals gene expression and DNA methylation patterns in osteoarthritis

D Song, W Qi, M Lv, C Yuan… - Molecular Medicine …, 2018 - spandidos-publications.com
Osteoarthritis (OA) is a common type of arthritis, which may cause pain and disability.
Alterations in gene expression and DNA methylation have been proven to be associated …

[HTML][HTML] Effect of DNA methylation on gene transcription is associated with the distribution of methylation sites across the genome in osteoarthritis

P Yi, X Xu, J Yao, B Qiu - … and Therapeutic Medicine, 2021 - spandidos-publications.com
Genetics and epigenetics are important subjects in the field of osteoarthritis (OA) research.
DNA methylation may affect gene transcription, but the specific mechanisms have remained …

Quantitative analysis of DNA methylation-related proteins in patients with knee osteoarthritis

Z Cai, T Long, Y Wang - 2023 - researchsquare.com
Background Knee osteoarthritis is a common musculoskeletal disease characterized by
degeneration of articular cartilage. Current diagnostic tools are limited to radiographs and …

[HTML][HTML] Aberrantly hydroxymethylated differentially expressed genes and the associated protein pathways in osteoarthritis

Y Fang, P Wang, L Xia, S Bai, Y Shen, Q Li, Y Wang… - PeerJ, 2019 - peerj.com
Background The elderly population is at risk of osteoarthritis (OA), a common, multifactorial,
degenerative joint disease. Environmental, genetic, and epigenetic (such as DNA …

Genome‐wide expression and methylation profiles reveal candidate genes and biological processes underlying synovial inflammatory tissue of patients with …

J Yang, N Wang - International journal of rheumatic diseases, 2015 - Wiley Online Library
Aim The aim of the study was to identify osteoarthritis (OA)‐related biological markers and
processes. Methods The gene expression profile GSE 46750 including 12 normal and 12 …