X chromosome inactivation is the epitome of epigenetic regulation and long non-coding
ribonucleic acid function. The differentiation status of cells has been ascribed to X …

X-chromosome inactivation represents an epigenetics paradigm and a powerful model
system of facultative heterochromatin formation triggered by a non-coding RNA, Xist, during …

Highlights•Inactivation of one X chromosome in female cells levels X-linked gene dosage to
males.•The number of known Xist RNA interactor proteins and its functions have widely …

Disappearance of the Barr body is considered a hallmark of cancer, although whether this
corresponds to genetic loss or to epigenetic instability and transcriptional reactivation is …

Background X inactive-specific transcript (XIST) RNA is involved in X chromosome silencing
in female cells and allows X chromosome equilibration with males. X inactive-specific …

In an XX female, one of the two X chromosomes has been inactivated during early
embryonic life to achieve a compensation of X-linked gene products between males and …

Development of cervical carcinomas is strongly associated with presence of human
papilloma virus (HPV). Recently we found that young patients with breast cancer had a …

The skewed X chromosome inactivation (SXCI) was found mainly in adult females. It has
been linked to development of ovarian and breast cancers. The present study aimed to …

The interpretation of loss of heterozygosity (LOH) in cancers is complicated as genes that
map to LOH regions may be transcriptionally active (Xa) or inactive (Xi) due to X …

Loss of Y-chromosome has been correlated with older age in males. Furthermore, current
evidence indicates that Y-chromosome loss also occurs in several human tumors, including …