Reduced quality in oocytes from women of advanced maternal age (AMA) is associated with
dysfunctional mitochondria. The objective of this study was to investigate the mechanisms …

Mitochondria affect numerous aspects of mammalian reproduction. We investigated whether
the decrease in oocyte quality associated with aging is related to altered mitochondria …

Oocytes from aging ovaries contain mitochondria with morphological and genetic flaws. How
these flaws relate to phenotypes of oocyte developmental compromise associated with …

The objective of this work was to determine the role of mitochondria in the loss of oocyte
quality with maternal aging. Our results show that mitochondrial DNA (mtDNA) copy number …

Purpose To establish the phenotype of reproductive aging in our mouse model. To test the
hypotheses that reproductive aging is associated with a decrease in mitochondrial …

Purpose The number of women attempting to conceive between the ages of 36 and 44 has
increased significantly in the last decade. While it is well established that women's …

STUDY QUESTION Does in vivo aging of mouse oocytes affect mitochondrial function?
SUMMARY ANSWER Mitochondrial function was impaired in post-ovulatory in vivo-aged …

Mitochondria play a central role in the regulation of energy metabolism in oocytes and
preimplantation embryos, where the number and morphology of mitochondria and …

There is a worldwide trend for women to have their first pregnancy later in life. However, as
oocyte quality declines with maternal aging, this trend leads to an increase in subfertility …

The oocyte is recognised as the largest cell in mammalian species and other multicellular
organisms. Mitochondria represent a high proportion of the cytoplasm in oocytes and …