Nanoparticles have an enormous potential for development in biomedical applications, such
as gene or drug delivery. We developed and characterized aminopropyltriethoxysilane …

In order to develop a safe and effective gene therapy carrier, some toxicological and
biodynamical experiments were carried out on silica nanoparticles (SiNPs). First we …

The potential of cationic SiO2 nanoparticles was investigated for in vivo gene transfer in this
study. Cationic SiO2 nanoparticles with surface modification were generated using amino …

Poly-L-lysine-modified silica nanoparticles (PMS-NP) is a novel nonviral vector for gene
delivery, which can efficiently deliver plasmid DNA and antisense oligonucleotides into …

Development of reliable vectors is a major challenge in gene therapy. Previous gene
transfer methods using non-viral vectors, such as liposomes or nanoparticles, have resulted …

Organic-inorganic hybrid silica nanoparticles (PM-1, PM-2 and PM-3) with positive surface
charge and size below 200 nm were one-pot prepared viaMichael addition between 3 …

DNA delivery is a core technology for gene structure and function research as well as
clinical settings. The ability to safely and efficiently targeted transfer foreign DNA into cells is …

Silica-based nanoparticles are promising carriers for gene delivery applications. To gain
insights into the effect of particle size on gene transfection efficiency, amine-modified …

Diverse polycationic polymers have been used as nonviral transfection agents. Here we
report the ability of colloidal silica particles with covalently attached cationic surface …

Uniform-sized amino-modified silica nanoparticles have been prepared by the controlled
synchronous hydrolysis of tetraethoxysilane and N-(β-amimoethyl)-γ …