Recent progress in biological activities of indole and indole alkaloids

TP Singh, OM Singh - Mini reviews in medicinal chemistry, 2018 - ingentaconnect.com
The indole scaffold is found in a wide range of bioactive heterocycles and natural products.
Moreover, the indole moiety is considered as the active principle in several alkaloids such …

Indoles as therapeutics of interest in medicinal chemistry: Bird's eye view

N Chadha, O Silakari - European Journal of Medicinal Chemistry, 2017 - Elsevier
Indoles constitute extensively explored heterocyclic ring systems with wide range of
applications in pathophysiological conditions that is, cancer, microbial and viral infections …

The Multi‐Pharmacological Targeted Role of Indole and its Derivatives: A review

B Suliphuldevara Mathada… - …, 2023 - Wiley Online Library
Heterocycles are a privileged motif that appears as a momentous objective in medicinal
chemistry. An important class of compounds for drug discovery and design is indole and its …

Medicinal perspective of indole derivatives: recent developments and structure-activity relationship studies

D Kumar, S Sharma, S Kalra, G Singh… - Current drug …, 2020 - ingentaconnect.com
Heterocyclic compounds play a significant role in various biological processes of the human
body and many of them are in clinical use due to their diverse, chemical and biological …

Indoles—A promising scaffold for drug development

TV Sravanthi, SL Manju - European Journal of Pharmaceutical Sciences, 2016 - Elsevier
Generally, heterocycles occupy a prominent place in chemistry due to their wide range of
applications in the fields of drug design, photochemistry, agrochemicals, dyes and so on …

Medicinal chemistry of indole derivatives: Current to future therapeutic prospectives

A Kumari, RK Singh - Bioorganic chemistry, 2019 - Elsevier
Indole is a versatile pharmacophore, a privileged scaffold and an outstanding heterocyclic
compound with wide ranges of pharmacological activities due to different mechanisms of …

[HTML][HTML] Synthesis of indole derivatives as prevalent moieties present in selected alkaloids

MM Heravi, Z Amiri, K Kafshdarzadeh, V Zadsirjan - RSC advances, 2021 - pubs.rsc.org
Indoles are a significant heterocyclic system in natural products and drugs. They are
important types of molecules and natural products and play a main role in cell biology. The …

An insight into the medicinal perspective of synthetic analogs of indole: A review

PV Thanikachalam, RK Maurya, V Garg… - European journal of …, 2019 - Elsevier
Heterocycles occupy a salient place in chemistry due to their wide range of activity in the
fields of drug design, photochemistry, agrochemicals, dyes, and so on. Amongst all, indole …

[HTML][HTML] Plant-based indole alkaloids: A comprehensive overview from a pharmacological perspective

F Omar, AM Tareq, AM Alqahtani, K Dhama… - Molecules, 2021 - mdpi.com
Plant-based indole alkaloids are very rich in pharmacological activities, and the indole
nucleus is considered to contribute greatly to these activities. This review's fundamental …

From nature to drug discovery: the indole scaffold as a 'privileged structure'

FR de Sa Alves, EJ Barreiro… - Mini reviews in …, 2009 - ingentaconnect.com
The indole scaffold probably represents one of the most important structural subunits for the
discovery of new drug candidates. The demonstration that many alkaloids contain the indole …