Microbial cells operate under governing constraints that limit their range of possible
functions. With the availability of annotated genome sequences, it has become possible to …

The manner in which microorganisms utilize their metabolic processes can be predicted
using constraint-based analysis of genome-scale metabolic networks. Herein, we present …

Constraint-based reconstruction and analysis (COBRA) methods at the genome scale have
been under development since the first whole-genome sequences appeared in the mid …

Abstract Systems analysis of metabolic and growth functions in microbial organisms is
rapidly developing and maturing. Such studies are enabled by reconstruction, at the …

System‐level analyses of microbial metabolism are facilitated by genome‐scale
reconstructions of microbial biochemical networks. A reconstruction provides a structured …

Reconstructed microbial metabolic networks facilitate a mechanistic description of the
genotype–phenotype relationship through the deployment of constraint-based …

Biochemical network reconstructions have become popular tools in systems biology.
Metabolicnetwork reconstructions are biochemically, genetically, and genomically (BiGG) …

Abstract Background COnstraint-Based Reconstruction and Analysis (COBRA) methods are
widely used for genome-scale modeling of metabolic networks in both prokaryotes and …

Genome-scale metabolic networks have been reconstructed for several organisms. These
metabolic networks provide detailed information about the metabolism inside the cells …

Genome-scale metabolic network reconstructions in microorganisms have been formulated
and studied for about 8 years. The constraint-based approach has shown great promise in …