BACKGROUND: Constipation is an uncomfortable and common condition that affects many,
irrespective of age. Since 1500 BC and before, health care practitioners have provided …

Laxatives are commonly used to treat constipation and can be bought over-the-counter in
many countries, although some preparations need to be prescribed by physicians. A meta …

Background Although constipation can be a chronic and severe problem, it is largely treated
empirically. Evidence for the efficacy of some of the older laxatives from well‐designed trials …

Background There has been no definitive systematic review and meta-analysis to date
examining the effect of laxatives and pharmacological therapies in chronic idiopathic …

OBJECTIVES Constipation is common, and its treatment is unsatisfactory. Although many
agents have been tried, there are limited data to support their use. Our aim was to undertake …

Constipation is a common gastrointestinal motility disorder that is often chronic, negatively
affects patients' daily lives, and is associated with high healthcare costs. There is a …

Constipated patients who are refractory to simple lifestyle interventions will usually resort to
laxatives, whether prescribed or over the counter. Clinical trial evidence is scarce for older …

Chronic constipation (CC) is a common gastrointestinal disorder with a varying prevalence
depending on the definition used to establish the diagnosis. Overall, 12%–19% of …

Pharmacological management of constipation Page 1 Pharmacological management of
constipation AV EMMANUEL,* J. TACK, EM QUIGLEYà & NJ TALLEY§ *Physiology Unit …

Introduction The increasing global prevalence of the symptoms of constipation adversely
affects the quality of life (QOL) of symptomatic patients. An acceptable universal definition of …