[HTML][HTML] Haploinsufficient Rock1+/− and Rock2+/− Mice Are Not Protected from Cardiac Inflammation and Postinflammatory Fibrosis in Experimental Autoimmune …
K Tkacz, F Rolski, M Czepiel, E Działo, M Siedlar… - Cells, 2020 - mdpi.com
Progressive cardiac fibrosis is a common cause of heart failure. Rho-associated, coiled-coil-
containing protein kinases (ROCKs) have been shown to enhance fibrotic processes in the …
containing protein kinases (ROCKs) have been shown to enhance fibrotic processes in the …
Reducing proteoglycan synthesis and NOX activity by ROCK inhibitors: therapeutic targets in atherosclerosis
H Babaahmadi-Rezaei, M Rezaei… - … Metabolic & Immune …, 2022 - ingentaconnect.com
Atherosclerosis is a chronic inflammatory disease of the arteries characterized by the
accumulation of inflammatory cells in the arterial wall. Hypertension, dyslipidemia, and …
accumulation of inflammatory cells in the arterial wall. Hypertension, dyslipidemia, and …
[HTML][HTML] The physiology, pathology, and therapeutic interventions for ROCK isoforms in diabetic kidney disease
K Matoba, Y Takeda, Y Nagai, K Sekiguchi… - Frontiers in …, 2020 - frontiersin.org
Rho-associated coiled-coil-containing protein kinase (ROCK) is a serine/threonine kinase
that was originally identified as RhoA interacting protein. A diverse array of cellular …
that was originally identified as RhoA interacting protein. A diverse array of cellular …
[HTML][HTML] FHL2 prevents cardiac hypertrophy in mice with cardiac-specific deletion of ROCK2
The Rho-associated coiled-coil containing kinases, ROCK1 and ROCK2, are important
regulators of cell shape, migration, and proliferation through effects on the actin …
regulators of cell shape, migration, and proliferation through effects on the actin …
[HTML][HTML] Increased leukocyte rho kinase (ROCK) activity and endothelial dysfunction in cigarette smokers
T Hidaka, T Hata, J Soga, Y Fujii, N Idei… - Hypertension …, 2010 - nature.com
Rho-associated kinases (ROCKs) have been shown to be involved in the pathogenesis of
atherosclerosis. Although smoking is associated with endothelial dysfunction and ROCK …
atherosclerosis. Although smoking is associated with endothelial dysfunction and ROCK …
Activation of Rho kinase isoforms in lung endothelial cells during inflammation
PY Mong, Q Wang - The Journal of Immunology, 2009 - journals.aai.org
Rho kinase (ROCK) is a downstream effector of Rho family GTPases, and two highly
homologous isoforms, ROCK1 and ROCK2, are similarly inhibited by the widely used …
homologous isoforms, ROCK1 and ROCK2, are similarly inhibited by the widely used …
[HTML][HTML] RUNX2-upregulated RANKL in calcifying smooth muscle cells promotes migration and osteoclastic differentiation of macrophages
CH Byon, Y Sun, J Chen, K Yuan, X Mao… - … , and vascular biology, 2011 - ncbi.nlm.nih.gov
Objective Clinical and experimental studies demonstrate the important roles of vascular
smooth muscle cells (VSMC) in the pathogenesis of atherosclerosis. We have previously …
smooth muscle cells (VSMC) in the pathogenesis of atherosclerosis. We have previously …
Runx2-upregulated receptor activator of nuclear factor κB ligand in calcifying smooth muscle cells promotes migration and osteoclastic differentiation of macrophages
CH Byon, Y Sun, J Chen, K Yuan, X Mao… - … , and vascular biology, 2011 - Am Heart Assoc
Objective—Clinical and experimental studies demonstrate the important roles of vascular
smooth muscle cells (VSMC) in the pathogenesis of atherosclerosis. We have previously …
smooth muscle cells (VSMC) in the pathogenesis of atherosclerosis. We have previously …
Targeting Rho-associated coiled-coil forming protein kinase (ROCK) in cardiovascular fibrosis and stiffening
Introduction: Pathological cardiac fibrosis, through excessive extracellular matrix protein
deposition from fibroblasts and pro-fibrotic immune responses and vascular stiffening is …
deposition from fibroblasts and pro-fibrotic immune responses and vascular stiffening is …