Introduction: Pathological cardiac fibrosis, through excessive extracellular matrix protein
deposition from fibroblasts and pro-fibrotic immune responses and vascular stiffening is …

ROCKs are important regulators of the actin cytoskeleton. Because changes in the actin
cytoskeleton underlie vascular contractility and remodeling, inflammatory cell recruitment …

The ability of stem cells to rapidly proliferate and differentiate is integral to the steady-state
maintenance of tissues with high turnover such as the blood and intestine. Mutations that …

Abstract The small GTPase RhoA and its downstream effectors, ROCK1 and ROCK2,
regulate a number of cellular processes, including cell motility, proliferation, survival, and …

Rho-kinase (ROCKs) is an important downstream effector of the small GTP-binding protein
Ras homolog gene family member A. There are 2 isoforms of ROCK, ROCK1 and ROCK2 …

We read the recently published article titled “ROCK2 promotes ryanodine receptor
phosphorylation and arrhythmic calcium release in diabetic cardiomyocytes” by Soliman H …

Pathological cardiac hypertrophy caused by diverse etiologies eventually leads to cardiac
dilation and functional decompensation. We have recently reported that genetic deletion of …

Objective—Cardiovascular diseases are associated with chronic activation of Rho-
associated kinases (ROCKs) and endothelial dysfunction. Both increased ROCK activity and …

Abstract The small GTPase Rho and its effector Rho kinase (ROCK) are involved in the
pathogenesis of diabetic kidney disease. Rho kinase has two isoforms: ROCK1 and ROCK2 …

Balanced regulation of cytokine secretion in T cells is critical for maintenance of immune
homeostasis and prevention of autoimmunity. The Rho-associated kinase (ROCK) 2 …