Although many individuals achieve weight loss of 10% or more, the ability to maintain a
reduced body mass over months and years is much rarer. Unfortunately, our understanding …

Although many persons with obesity can lose weight by lifestyle (diet and physical activity)
therapy, successful long‐term weight loss is difficult to achieve, and most people who lose …

Dieting is the most common approach to losing weight for the majority of obese and
overweight individuals. Restricting intake leads to weight loss in the short term, but, by itself …

Although weight loss can usually be achieved by restricting food intake, the majority of
dieters regain weight over the long-term. In the hypothalamus, hormonal signals from the …

Obesity is a world‐wide pandemic and its incidence is on the rise along with associated
comorbidities. Currently, there are few effective therapies to combat obesity. The use of …

Obesity is a chronic disease that affects more than 650 million adults worldwide. Obesity not
only is a significant health concern on its own, but predisposes to cardiometabolic …

Weight loss dieting remains the treatment of choice for the vast majority of obese individuals,
despite the limited long-term success of behavioral weight loss interventions. The reasons …

Human biology has evolved to keep body fat within a range that supports survival. During
the last 25 years, obesity biologists have uncovered key aspects of physiology that prevent …

Obesity is among the most common and costly chronic disorders worldwide. Estimates
suggest that in the United States obesity affects one-third of adults, accounts for up to one …

The discovery of leptin, an adipocyte-secreted hormone, set the stage for unraveling the
mechanisms dictating energy homeostasis, revealing adipose tissue as an endocrine …