Clonally expanded populations of B cells carrying somatic mutations of Ig variable (V) region
genes have been detected in the CNS of subjects with multiple sclerosis (MS), suggesting …

The accumulation of B lymphocyte clones in the cerebrospinal fluid (CSF) of patients with
multiple sclerosis (MS) and patients with other neurological disorders was investigated …

Single-cell RT-PCR was used to sample CD19+ B cell repertoires in cerebrospinal fluid
(CSF) of patients with multiple sclerosis (MS) or viral meningitis. Analysis of amplified Ab H …

Multiple sclerosis (MS) lesions in the CNS are characterized by disseminated demyelination
with perivascular infiltrates of macrophages, T cells, and B cells. To investigate the origin …

The development of somatically mutated memory and plasma B cells is a consequence of T
cell-dependent antigen-challenged humoral immunity. To investigate the role of B cell …

In multiple sclerosis (MS), lymphocyte—in particular B cell—transit between the central
nervous system (CNS) and periphery may contribute to the maintenance of active disease …

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS)
characterized by autoimmune-mediated demyelination and neurodegeneration. The CNS of …

Objective Results from anti‐CD20 therapies demonstrate that B‐and T‐cell interaction is a
major driver of multiple sclerosis (MS). The local presence of B‐cell follicle‐like structures …

Increased amounts of intrathecally synthesized IgG and oligoclonal bands have long been
recognized as a hallmark of multiple sclerosis (MS). B cells and plasma cells are …

Given the abnormalities in B-cell activity occurring in the central nervous system (CNS) of
patients with multiple sclerosis (MS), we have explored the possibility that CNS inflammation …