RNA plays a central role in the expression of all genes. Because any sequence within RNA
can be recognized by complementary base pairing, synthetic oligonucleotides and …

Antisense oligonucleotides have the potential to make revolutionary contributions to basic
science and medicine. Oligonucleotides can bind mRNA and inhibit translation. Because …

The use of antisense oligonucleotides as therapeutic agents has generated considerable
enthusiasm in the research and medical community. Antisense oligonucleotides as …

Antisense Research and Applications is a comprehensive review of oligonucleotide
research covering molecular biological advances in this field, the current status of antisense …

Antisense oligonucleotides provide a simple and efficient approach for developing target-
selective drugs because they can modulate gene expression sequence-specifically …

Recently, there is a hopefully tremendous interest in antisense therapeutics for clinical
purposes. Single‐stranded synthetic antisense oligonucleotides (As‐ODNs) with monomers …

Antisense oligonucleotides are widely used as tools to explore the pharmacological effects
of inhibiting expression of a selected gene product. In addition, they are being investigated …

In the past decade, there has been a vast increase in the amount of gene sequence
information that has the potential to revolutionize the way diseases are both categorized and …

Recent studies have led to a greater appreciation of the diverse roles RNAs play in
maintaining normal cellular function and how they contribute to disease pathology …

Eighteen years ago, antisense oligonucleotide therapeutics that can selectively knock out
disease-causing genes could easily have been viewed as science fiction. Yet today, through …