Genome editing using the CRISPR-Cas system has vastly advanced the ability to precisely
edit the genomes of various organisms. In the context of mammalian cells, this technology …

The clustered regularly interspaced short palindromic repeats (CRISPR) system functions
naturally in bacterial adaptive immunity, but has been successfully repurposed for genome …

Over the past years, CRISPR/Cas9 mediated genome editing has developed into a powerful
tool for modifying genomes in various organisms. In high-throughput screens, CRISPR/Cas9 …

Forward genetic screens are a powerful and unbiased approach for uncovering the genetic
basis behind a specific phenotype. Genome-wide mutagenesis followed by phenotypic …

CRISPR genome editing approaches theoretically enable researchers to define the function
of each human gene in specific cell types, but challenges remain to efficiently perform …

In the postgenomic era, the ability to quickly, efficiently, and inexpensively assign function to
the zebrafish proteome is critical. Clustered regularly interspaced short palindromic repeats …

The creation of genome-wide libraries for CRISPR knockout (CRISPRko), interference
(CRISPRi), and activation (CRISPRa) has enabled the systematic interrogation of gene …

As a powerful genome‐editing tool, the clustered regularly interspaced short palindromic
repeats (CRISPR)‐clustered regularly interspaced short palindromic repeats‐associated …

The CRISPR-Cas system offers a programmable platform for eukaryotic genome and
epigenome editing. The ability to perform targeted genetic and epigenetic perturbations …

CRISPR technology has rapidly changed the face of biological research, such that precise
genome editing has now become routine for many labs within several years of its initial …