Elevated T cell counts and RANTES expression in the genital mucosa of HIV-1–resistant Kenyan commercial sex workers
The initial site of exposure to human immunodeficiency virus (HIV)–1 during heterosexual
transmission occurs in the genital tract. Although the majority of immunological studies have …
transmission occurs in the genital tract. Although the majority of immunological studies have …
HIV-1-specific mucosal CD8+ lymphocyte responses in the cervix of HIV-1-resistant prostitutes in Nairobi
Understanding how individuals with a high degree of HIV exposure avoid persistent
infection is paramount to HIV vaccine design. Evidence suggests that mucosal immunity …
infection is paramount to HIV vaccine design. Evidence suggests that mucosal immunity …
Characterization of a human cervical CD4+ T cell subset coexpressing multiple markers of HIV susceptibility
LR McKinnon, B Nyanga, D Chege, P Izulla… - The Journal of …, 2011 - journals.aai.org
The HIV pandemic disproportionately affects women, with most infections acquired through
receptive vaginal sex. Although the target cells by which HIV establishes infection in the …
receptive vaginal sex. Although the target cells by which HIV establishes infection in the …
Increased levels of immune activation in the genital tract of healthy young women from sub-Saharan Africa
Objectives: To determine whether healthy, young women in sub-Saharan Africa have a more
activated immune milieu in the genital tract (ie activated CD4+ T cells) than a similar …
activated immune milieu in the genital tract (ie activated CD4+ T cells) than a similar …
[HTML][HTML] A distinct cytokine and chemokine profile at the genital mucosa is associated with HIV-1 protection among HIV-exposed seronegative commercial sex workers
J Lajoie, J Juno, A Burgener, S Rahman, K Mogk… - Mucosal …, 2012 - Elsevier
The predominance of HIV-1 sexual transmission requires a greater understanding of the
interaction between HIV-1 and the mucosal immune system. The study of HIV-1-exposed …
interaction between HIV-1 and the mucosal immune system. The study of HIV-1-exposed …
HIV-1 Env-specific cytotoxic T-lymphocyte responses in exposed, uninfected Kenyan sex workers: a prospective analysis
The prospective significance of HIV-specific cytotoxic T lymphocyte (CTL) responses in
highly exposed, persistently seronegative populations is unknown. In 1996–1997 we …
highly exposed, persistently seronegative populations is unknown. In 1996–1997 we …
New insights into HIV-1 specific cytotoxic T-lymphocyte responses in exposed, persistently seronegative Kenyan sex workers
A clearer understanding of HIV-1 specific immune responses in highly-exposed, persistently
seronegative (HEPS) subjects is important in developing models of HIV-1 protective …
seronegative (HEPS) subjects is important in developing models of HIV-1 protective …
HIV-1-specific mucosal IgA in a cohort of HIV-1-resistant Kenyan sex workers
Objectives: Most HIV-1 transmission is sexual; therefore, immune responses in the genital
mucosa may be important in mediating protection against HIV infection. This study examined …
mucosa may be important in mediating protection against HIV infection. This study examined …
Quantitative ex vivo analysis of functional virus-specific CD8 T lymphocytes in the blood and genital tract of HIV-infected women
Background: CD8 T lymphocytes are important in HIV-1 control and mediate virus-specific
immunity in the blood and genital tract. The induction and monitoring of mucosal CD8 cell …
immunity in the blood and genital tract. The induction and monitoring of mucosal CD8 cell …
[HTML][HTML] Immune correlates of HIV exposure without infection in foreskins of men from Rakai, Uganda
JL Prodger, T Hirbod, G Kigozi, F Nalugoda… - Mucosal …, 2014 - Elsevier
Human immunodeficiency virus (HIV) susceptibility is heterogenous, with some HIV-
exposed but seronegative (HESN) individuals remaining uninfected despite repeated …
exposed but seronegative (HESN) individuals remaining uninfected despite repeated …