Sorafenib derivatives-functionalized gold nanoparticles confer protection against tumor angiogenesis and proliferation via suppression of EGFR and VEGFR-2

W Huang, Y Xing, L Zhu, J Zhuo, M Cai - Experimental Cell Research, 2021 - Elsevier
Sorafenib is a multi-kinase inhibitor that has been highlighted as a tumor suppressor due to
its anti-proliferative and anti-angiogenic properties, whereas the clinical application of …

Gold nanoparticles attenuate metastasis by tumor vasculature normalization and epithelial–mesenchymal transition inhibition

W Li, X Li, S Liu, W Yang, F Pan, XY Yang… - International journal …, 2017 - Taylor & Francis
Angiogenesis is a process by which vessels are formed through preexisting ones, and this
plays a key role in the progression of solid tumors. However, tumor vessels are influenced …

Gold nanoparticles induce nanostructural reorganization of VEGFR2 to repress angiogenesis

Y Pan, H Ding, L Qin, X Zhao, J Cai… - Journal of biomedical …, 2013 - ingentaconnect.com
The inhibition of the binding between VEGFs and their receptors reduces angiogenesis and
retards tumor growth. Owing to the large amount of antibodies required, the antibody-based …

Cellular localization and biological effects of 20nm‐gold nanoparticles

G Tan, MA Onur - … of Biomedical Materials Research Part A, 2018 - Wiley Online Library
Gold nanoparticles (AuNPs) have recently emerged as prominent vehicles for many
biomedical applications from sensing to delivery. The relevant literature contains conflicting …

Gold nanoparticles induce tumor vessel normalization and impair metastasis by inhibiting endothelial Smad2/3 signaling

N Huang, Y Liu, Y Fang, S Zheng, J Wu, M Wang… - ACS …, 2020 - ACS Publications
Gold nanoparticles (AuNPs) are a promising nanomaterial due to their drug-delivery
properties and inherent anti-neoplastic activity. Here, we focused on the anti-neoplastic …

Inhibition effects of gold nanoparticles on proliferation and migration in hepatic carcinoma-conditioned HUVECs

Y Pan, Q Wu, R Liu, M Shao, J Pi, X Zhao… - Bioorganic & medicinal …, 2014 - Elsevier
Tumor angiogenesis is a complicated process based upon a sequence of interactions
between tumor and vessel endothelial cells. Tumor conditioned medium has been widely …

In situ biosynthesized gold nanoclusters inhibiting cancer development via the PI3K–AKT signaling pathway

M Wang, Z Yu, H Feng, J Wang, L Wang… - Journal of Materials …, 2019 - pubs.rsc.org
Nanomaterials have made great breakthroughs in drug delivery. However, in previous
studies, nanomaterials have been mostly used as vehicles to transport drugs into tumors …

Green synthesized apigenin conjugated gold nanoparticles inhibit cholangiocarcinoma cell activity and endothelial cell angiogenesis in vitro

N Ngernyuang, M Wongwattanakul, W Charusirisawad… - Heliyon, 2022 - cell.com
Cholangiocarcinoma (CCA) is a rare malignancy of the biliary tract with extremely poor
clinical outcomes due to a lack of effective therapies to improve disease management. The …

Anti-proliferative effects of gold nanoparticles functionalized with semaphorin 3F

G Tan, MA Onur - Journal of Nanoparticle Research, 2017 - Springer
The new vessel formations play a vital role in growth and spread of cancer. Current anti-
angiogenic therapies, predominantly based on vascular endothelial growth factor (VEGF) …

Nano-gold loaded with resveratrol enhance the anti-hepatoma effect of resveratrol in vitro and in vivo

D Zhang, J Zhang, J Zeng, Z Li, H Zuo… - Journal of …, 2019 - ingentaconnect.com
Nanomaterials-based drug delivery systems display potent applications in cancer therapy.
We synthesized a novel anticancer drug, nano-gold loaded with resveratrol (Res-GNPs) …