The 'ataxia telangiectasia mutated'(Atm) gene maintains genomic stability by activating a key
cell-cycle checkpoint in response to DNA damage, telomeric instability or oxidative stress …

Ataxia-telangiectasia (AT) results from the loss of ataxia-telangiectasia mutated (Atm)
function and is characterized by accelerated telomere loss, genomic instability, progressive …

Ataxia telangiectasia (AT) is a rare human autosomal recessive disorder with pleiotropic
phenotypes, including neuronal degeneration, immune dysfunction, premature ageing and …

The gene mutated in the autosomal recessive disorder ataxia telangiectasia (AT),
designated ATM (for'AT mutated'), is a member of a family of phosphatidylinositol-3-kinase …

The ATM (ataxia-telangiectasia mutated) protein kinase mediates early cellular responses to
DNA double-strand breaks (DSBs) generated during metabolic processes or by DNA …

The ATM protein kinase, mutations of which are associated with the human disease ataxia–
telangiectasia, mediates responses to ionizing radiation in mammalian cells. Here we show …

Ataxia telangiectasia (AT) mutated (ATM) kinase orchestrates deoxyribonucleic acid (DNA)
damage responses by phosphorylating numerous substrates implicated in DNA repair and …

A murine model of ataxia telangiectasia was created by disrupting the Atm locus via gene
targeting. Mice homozygous for the disrupted Atm allele displayed growth retardation …

Hematopoietic stem cells (HSCs) undergo self-renewing cell divisions and maintain blood
production for their lifetime. Appropriate control of HSC self-renewal is crucial for the …

Abstract Ataxia‐telangiectasia (A‐T) is a pleiotropic recessive disorder characterized
cerebellar ataxia, immunodeficiency, specific developmental defects, profound …