Gap junctions (GJs) are composed of proteins that form a channel connecting the cytoplasm
of adjacent cells. Connexins were initially considered to be the only proteins capable of GJ …

Connexins had been considered to be the only class of the vertebrate proteins capable of
gap junction formation; however, new candidates for this function with no homology to …

Vertebrates express two families of gap junction proteins: the well characterized connexins
and the recently discovered pannexins. The latter are related to invertebrate innexins. Here …

Pannexins, a class of membrane channels, bear significant sequence homology with the
invertebrate gap junction proteins, innexins, and more distant similarities in their membrane …

Direct cell-to-cell communication through specialized intercellular channels is a
characteristic feature of virtually all multi-cellular organisms. The remarkable functional …

Database search has led to the identification of a family of proteins, the pannexins, which
share some structural features with the gap junction forming proteins of invertebrates and …

We have cloned the genes PANX1, PANX2 and PANX3, encoding putative gap junction
proteins homologous to invertebrate innexins, which constitute a new family of mammalian …

Pannexins are homologous to innexins, the invertebrate gap junction family. However,
mammalian pannexin1 does not form canonical gap junctions, instead forming hexameric …

Pannexins are mammalian orthologs of the invertebrate gap junction proteins innexins and
thus have been proposed to play a role in gap junctional intercellular communication …

Intercellular communication (IC) is mediated by gap junctions (GJs) and hemichannels,
which consist of proteins. This has been particularly well documented for the connexin (Cx) …