The advent of multicellular organisms, some 800 million years ago, necessitated the
development of mechanisms for cell-to-cell synchronization and for the spread of signals …

Coordinated interaction among cells is critical to develop the extremely complex and
dynamic tasks performed by the central nervous system (CNS). Cell synchronization is in …

Pannexins were originally thought to represent a second and redundant family of gap
junction proteins in addition to the well characterized connexins. However, it is now evident …

Pannexin1 (Panx1) originally was discovered as a gap junction related protein. However,
rather than forming the cell-to-cell channels of gap junctions, Panx1 forms a …

The expression pattern of pannexin1, a gene coding for a protein that forms gap junction
channels, was studied as both mRNA and protein in the CNS of adult mouse. Pannexin1 …

Gap-junction-dependent neuronal communication is widespread in the developing brain,
and the prevalence of gap-junctional coupling is well correlated with specific developmental …

Pannexins are mammalian orthologs of innexins and have a predicted topological folding
pattern similar to that of connexins, except they are glycosylated. Rat pannexin1 is …

Dear Editor, Pannexin 1 (PANX1) plays extensive physiological roles across diverse fields of
biology, including cell death, 1, 2 inflammation, 3 cancer progression, 4 and neurological …

Evidence is accumulating that some forms of cell death, like apoptosis, are not only
governed by the complex interplay between extracellular and intracellular signals but are …

Pannexins are a class of plasma membrane spanning proteins that presumably form a
hexameric, non-selective ion channel. Although similar in secondary structure to the …