The role of dendritic cells in immune regulation and allergic airway inflammation

JW Upham - Respirology, 2003 - Wiley Online Library
Dendritic cells (DC) are potent antigen presenting cells that display an extraordinary
capacity to present antigen to naïve T‐cells and initiate primary immune responses. In the …

Why are dendritic cells important in allergic diseases of the respiratory tract?

JW Upham, PA Stumbles - Pharmacology & therapeutics, 2003 - Elsevier
Increasing evidence points to the role of antigen-presenting dendritic cells (DC) in regulating
adaptive immune responses. DC are especially sensitive to signals derived from microbes …

Recent progress in the biology of airway dendritic cells and implications for understanding the regulation of asthmatic inflammation

H Hammad, BN Lambrecht - Journal of allergy and clinical immunology, 2006 - Elsevier
Dendritic cells (DCs) are crucial in determining the outcome of antigen encounter and
integrating signals derived from the antigen, its inflammatory context, and the host …

Dendritic cells: pulmonary immune regulation and asthma.

BJ Masten, MF Lipscomb - … for Chest Disease= Archivio Monaldi per …, 2000 - europepmc.org
Dendritic cells (DCs) may play a pivotal role in the initiation and establishment of chronic T-
helper cell (Th)-2 mediated lung inflammation as seen in asthma. Current in vitro data …

Dendritic cells revisited in human allergic rhinitis and asthma

A Froidure, C Shen, C Pilette - Allergy, 2016 - Wiley Online Library
The role of dendritic cells (DC s) in airway allergy has been studied for 15 years; recent data
has highlighted the cross talk with airway epithelial cells and environmental factors …

Dendritic cells in allergic airway inflammation

AS Bharadwaj, AK Bewtra… - Canadian Journal of …, 2007 - cdnsciencepub.com
Dendritic cells (DCs) are primary antigen-presenting cells involved in interactions with T
cells leading to the proliferation of TH1 or TH2 cell types. In asthma, predominance of TH2 …

Dendritic cell subsets and immune regulation in the lung

HJ de Heer, H Hammad, M Kool, BN Lambrecht - Seminars in immunology, 2005 - Elsevier
The lung is continuously exposed to inhaled particles, microbes and harmless antigens to
which either immunity or tolerance is induced. Dendritic cells are mainly recognized for their …

Airway dendritic cells: Co‐ordinators of immunological homeostasis and immunity in the respiratory tract

PA Stumbles, JW Upham, PG Holt - Apmis, 2003 - Wiley Online Library
The large quantities and complex mixtures of antigens encountered daily at airway mucosal
and alveolar surfaces pose a major challenge to maintenance of immunological …

Regulatory dendritic cells protect against allergic airway inflammation in a murine asthmatic model

S Fujita, N Yamashita, Y Ishii, Y Sato, K Sato… - Journal of allergy and …, 2008 - Elsevier
BACKGROUND: Dendritic cells (DCs) are crucial for the induction of immunity and
tolerance. Despite an improved understanding of the DC-mediated control of TH1-biased …

Dendritic cells in asthma

MJ van Helden, BN Lambrecht - Current opinion in immunology, 2013 - Elsevier
Highlights•Dendritic cells (DCs) are essential for inducing Th2 immunity to several
allergens.•Similar to other organs, lung DCs are a heterogeneous population of …