The discovery of the molecular basis of this disease is expected to facilitate diagnosis and
definitive treatment with hematopoietic cell transplantation. Further research is needed to …

2. Engelhardt KR, McGhee S, Winkler S, Sassi A, Woellner C, Lopez-Herrera G, et al. Large
deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the …

Background Autosomal recessive loss-of-function mutations in dedicator of cytokinesis 8
(DOCK8) cause a combined immunodeficiency characterized by atopy, recurrent infections …

Highlights●DOCK8 deficiency features infection susceptibility and monogenic allergy.●T
FH 13 cell numbers are increased in DOCK8 deficiency and drive anaphylaxis.● …

Abstract Dedicator of cytokinesis 8 (DOCK8) deficiency is a combined immunodeficiency
that exemplifies the broad clinical features of primary immunodeficiencies (PIDs), extending …

Background Dedicator of cytokinesis 8 (DOCK8) deficiency is a combined immunodeficiency
caused by autosomal recessive loss-of-function mutations in DOCK8. This disorder is …

Background Recurrent sinopulmonary and cutaneous viral infections with elevated serum
levels of IgE are features of some variants of combined immunodeficiency. The genetic …

Background Dedicator of cytokinesis 8 (DOCK8) deficiency can be cured by allogeneic
hematopoietic stem cell transplantation (HSCT). Reports of outcomes are still limited …

Background Biallelic variations in the dedicator of cytokinesis 8 (DOCK8) gene cause a
combined immunodeficiency with eczema, recurrent bacterial and viral infections, and …

Biallelic mutations in the dedicator of cytokinesis 8 gene (DOCK8) cause a progressive
combined immunodeficiency (CID) characterized by susceptibility to severe viral skin …