Cyclin D1 overexpression is believed to be essential in the pathogenesis of mantle cell
lymphoma (MCL). Hence, the existence of cyclin D1-negative MCL has been controversial …

The prognosis for patients with mantle cell lymphoma (MCL) is poor, and at present there is
no truly effective therapy. Gene translocation-mediated constitutive expression of cyclin D1 …

Mantle cell lymphoma (MCL) is a distinct clinicopathologic entity of non-Hodgkin's
lymphoma, characterized by a monotonous proliferation of small to medium-sized …

Presence of the balanced translocation t (11; 14)(q13; q32) and the consequent
overexpression of cyclin D1 found in mantle cell lymphoma (MCL) has been shown to be of …

Mantle cell lymphoma (MCL) is a lymphoproliferative disorder with distinct pathologic and
clinical features. Genetically, the vast majority of MCLs carry the t (11; 14)(q13; q32). This …

Mantle cell lymphoma (MCL) is a clinicopathologic entity that is difficult to diagnose on
histopathologic criteria. Approximately 50% to 70% of MCL contain at (11; 14)(q13; q32) …

Mantle cell lymphoma (MCL) is a distinctive lymphoma type generally characterized by the
presence of CCND1 translocation and overexpression of cyclin D1. MCL usually presents …

Abstract Background: The t (11; 14)(q13; q32) translocation present in the majority of mantle
cell lymphomas (MCLs) places the cyclin D1 gene under the control of immunoglobulin …

Cyclin D1− mantle cell lymphomas (MCLs) are not well characterized, in part because of the
difficulties in their recognition. SOX11 has been identified recently as a reliable biomarker of …

Purpose To compare the genetic relationship between cyclin D1–positive and cyclin D1–
negative mantle cell lymphomas (MCLs) and to determine whether specific genetic …