Respiratory SARS-CoV-2 Infection Causes Skeletal Muscle Atrophy and Long-Lasting Energy Metabolism Suppression

ST Homma, X Wang, JJ Frere, AC Gower, J Zhou… - Biomedicines, 2024 - mdpi.com
Muscle fatigue represents the most prevalent symptom of long-term COVID, with elusive
pathogenic mechanisms. We performed a longitudinal study to characterize …

Skeletal muscle alterations in patients with acute Covid‐19 and post‐acute sequelae of Covid‐19

MN Soares, M Eggelbusch, E Naddaf… - Journal of cachexia …, 2022 - Wiley Online Library
Skeletal muscle‐related symptoms are common in both acute coronavirus disease (Covid)‐
19 and post‐acute sequelae of Covid‐19 (PASC). In this narrative review, we discuss …

Skeletal muscle damage in COVID-19: a call for action

AM Ali, H Kunugi - Medicina, 2021 - mdpi.com
Both laboratory investigations and body composition quantification measures (eg, computed
tomography, CT) portray muscle loss in symptomatic Coronavirus disease 2019 (COVID-19) …

Skeletal muscle in hypoxia and inflammation: insights on the COVID-19 pandemic

FG Di Girolamo, N Fiotti, UG Sisto, A Nunnari… - Frontiers in …, 2022 - frontiersin.org
SARS-CoV-2 infection is often associated with severe inflammation, oxidative stress,
hypoxia and impaired physical activity. These factors all together contribute to muscle …

[HTML][HTML] Synergistic effects of multiple factors involved in COVID-19-dependent muscle loss

N Cantu, S Vyavahare, S Kumar, J Chen… - Aging and …, 2022 - ncbi.nlm.nih.gov
The COVID-19 pandemic caused by the novel SARS-CoV-2 coronavirus is an ongoing
pandemic causing severe health crisis worldwide. Recovered COVID-19 patients go through …

Post-COVID syndrome is associated with capillary alterations, macrophage infiltration and distinct transcriptomic signatures in skeletal muscles

T Aschman, E Wyler, O Baum, A Hentschel, F Legler… - MedRxiv, 2023 - medrxiv.org
The SARS-CoV-2 pandemic not only resulted in millions of acute infections worldwide, but
also caused innumerable cases of post-infectious syndromes, colloquially referred to as …

Muscle dysfunction in the long coronavirus disease 2019 syndrome: Pathogenesis and clinical approach

CC Silva, CNC Bichara, FRO Carneiro… - Reviews in Medical …, 2022 - Wiley Online Library
In long coronavirus disease 2019 (long COVID‐19), involvement of the musculoskeletal
system is characterised by the persistence or appearance of symptoms such as fatigue …

Myopathy as a cause of fatigue in long‐term post‐COVID‐19 symptoms: Evidence of skeletal muscle histopathology

EK Hejbøl, T Harbo, J Agergaard… - European Journal of …, 2022 - Wiley Online Library
Background and purpose Among post‐COVID‐19 symptoms, fatigue is reported as one of
the most common, even after mild acute infection, and as the cause of fatigue, myopathy …

Acute skeletal muscle loss in SARS‐CoV‐2 infection contributes to poor clinical outcomes in COVID‐19 patients

A Attaway, N Welch, D Dasarathy… - Journal of cachexia …, 2022 - Wiley Online Library
Background Chronic disease causes skeletal muscle loss that contributes to morbidity and
mortality. There are limited data on the impact of dynamic muscle loss on clinical outcomes …

Unveiling the detrimental vicious cycle linking skeletal muscle and COVID‐19: A systematic review and meta‐analysis

Q Wang, P Shi, L Cao, H Li, X Chen… - Journal of Evidence …, 2024 - Wiley Online Library
Objective Skeletal muscle catabolism supports multiple organs and systems during severe
trauma and infection, but its role in COVID‐19 remains unclear. This study investigates the …