In preparation for a large efficacy trial in Germany, a pilot study was initiated in December
1990. In this study 149 infants were enrolled; with double-blind randomization 75 received …

The results of the following studies are reported: a longitudinal double blind trial comparing
Lederle-Takeda APDT vaccine with Lederle DTP vaccine in two, four and six month old …

In two double-blind, randomized, comparative studies involving a total of 218 children, an
acellular pertussis (DTPa) vaccine containing diphtheria and tetanus toxoids and pertussis …

In a multicenter, double-blind, randomized, longitudinal study, 252 children recelved
licensed Lederie diphtheria-tetanus toxoids and pertussis vaccine adsorbed (DTP) at 2, 4 …

• Objective.—To compare the reactogenicity and immune response to the Takeda acellular
pertussis-component diphtheria-tetanus-pertussis (APDT) vaccine in children when …

Background. The goal of the trial was to determine the efficacy of a multicomponent acellular
pertussis vaccine against Bordetella illnesses in comparison with a whole-cell product and …

Background. A household contact substudy was performed as part of a prospective, cohort
pertussis vaccine efficacy trial in Germany. Design. Infants received four doses of either the …

Minor adverse events were evaluated in a comparative efficacy trial in Germany in infants
who received either the Lederle/Takeda acellular pertussis component DTP (DTaP) vaccine …

Clinical and serological responses of infants to primary immunization with diphtheria-tetanus-
pertussis (DTP) vaccine containing components of acellular pertussis vaccine (DTP-AC) …

The objective of this open study was to monitor the long-term effectiveness of the Lederle-
Takeda diphtheria and tetanus toxoids and acellular pertussis antigen (s)(DTaP) vaccine …