Pollens destroy respiratory epithelial cell anchors and drive alphaherpesvirus infection

J Van Cleemput, KCK Poelaert, K Laval, F Impens… - Scientific reports, 2019 - nature.com
Pollens are well-known triggers of respiratory allergies and asthma. The pollen burden in
today's ambient air is constantly increasing due to rising climate change and air pollution …

Ligand recognition of the major birch pollen allergen Bet v 1 is isoform dependent

C Seutter von Loetzen, T Jacob, O Hartl-Spiegelhauer… - PLoS …, 2015 - journals.plos.org
Each spring millions of patients suffer from allergies when birch pollen is released into the
air. In most cases, the major pollen allergen Bet v 1 is the elicitor of the allergy symptoms …

Abundance and functional roles of intrinsic disorder in allergenic proteins and allergen representative peptides

B Xue, D Soeria‐Atmadja… - Proteins: Structure …, 2011 - Wiley Online Library
The pathological process of allergies generally involves an initial activation of certain
immune cells, tied to an ensuing inflammatory reaction on renewed contact with the …

Decoding the Folding of Burkholderia glumae Lipase: Folding Intermediates En Route to Kinetic Stability

K Pauwels, MM Sanchez del Pino, G Feller… - PLoS …, 2012 - journals.plos.org
The lipase produced by Burkholderia glumae folds spontaneously into an inactive near-
native state and requires a periplasmic chaperone to reach its final active and secretion …

Molecular dynamics of spike variants in the locked conformation: RBD interfaces, fatty acid binding and furin cleavage sites

DK Shoemark, ASF Oliveira, AD Davidson, I Berger… - bioRxiv, 2022 - biorxiv.org
Abstract Since December 2019 the SARS-CoV-2 virus has infected billions of people around
the world and caused millions of deaths. The ability for this RNA virus to mutate has …

Structural functionality, catalytic mechanism modeling and molecular allergenicity of phenylcoumaran benzylic ether reductase, an olive pollen (Ole e 12) allergen

JC Jimenez-Lopez, SO Kotchoni… - Journal of Computer …, 2013 - Springer
Isoflavone reductase-like proteins (IRLs) are enzymes with key roles in the metabolism of
diverse flavonoids. Last identified olive pollen allergen (Ole e 12) is an IRL relevant for …

The influence of recombinant production on the immunologic behavior of birch pollen isoallergens

M Wallner, M Himly, A Neubauer, A Erler, M Hauser… - PloS one, 2009 - journals.plos.org
Background Allergic reactions towards the birch major pollen allergen Bet v 1 are among the
most common causes of spring pollinosis in the temperate climate zone of the Northern …

Specific conformational epitope features of pathogenesis-related proteins mediating cross-reactivity between pollen and food allergens

JC Jimenez-Lopez, EW Gachomo, OA Ariyo… - Molecular biology …, 2012 - Springer
Selected members of plant pathogenesis-related and seed storage proteins represent
specific groups of proteins with potential characteristics of allergens. Efforts to understand …

Validation of capillary zone electrophoresis and capillary isoelectric focusing separations optimized for the characterization of two recombinant products of the birch …

B Kronsteiner, V Dullnig, H Stutz - Electrophoresis, 2008 - Wiley Online Library
CZE and CIEF separation systems, both developed previously for a quality control of two
recombinant products of the major birch pollen allergen Bet v 1a of Betula verrucosa, were …

X-ray and NMR structure of Bet v 1, the origin of birch pollen allergy

M Gajhede, P Osmark, FM Poulsen, H Ipsen… - Nature structural …, 1996 - nature.com
The three-dimensional structure of the major birch pollen allergen, the 17,500 M r acidic
protein Bet v 1 (from the birch, Betula verrucosa), is presented as determined both in the …