Investigation of lipid metabolism dysregulation and the effects on immune microenvironments in pan-cancer using multiple omics data

Y Hao, D Li, Y Xu, J Ouyang, Y Wang, Y Zhang, B Li… - BMC …, 2019 - Springer
Background Lipid metabolism reprogramming is a hallmark for tumor which contributes to
tumorigenesis and progression, but the commonality and difference of lipid metabolism …

Prognostic value of lipid metabolism‐related genes in head and neck squamous cell carcinoma

Y Xiong, Y Si, Y Feng, S Zhuo, B Cui… - Immunity, Inflammation …, 2021 - Wiley Online Library
Background Altered lipid metabolism is involved in the development of many tumors.
However, the role of dissimilar lipid metabolism in head and neck squamous cell carcinoma …

Prognosis and dissection of immunosuppressive microenvironment in breast cancer based on fatty acid metabolism-related signature

Y Tang, W Tian, J Xie, Y Zou, Z Wang, N Li… - Frontiers in …, 2022 - frontiersin.org
Fatty acid metabolism has been deciphered to augment tumorigenesis and disease
progression in addition to therapy resistance via strengthened lipid synthesis, storage, and …

A six lipid metabolism related gene signature for predicting the prognosis of hepatocellular carcinoma

K Xu, P Xia, P Liu, X Zhang - Scientific Reports, 2022 - nature.com
Globally, hepatocellular carcinoma (HCC) is one of the most lethal malignant tumors.
Studies have shown that alterations in the tumor immune microenvironment (TIME) play a …

Construction of a lipid metabolism‐related and immune‐associated prognostic signature for hepatocellular carcinoma

B Hu, XB Yang, XT Sang - Cancer medicine, 2020 - Wiley Online Library
Background Hepatocellular carcinoma (HCC) is one of the most lethal malignancies. We
aimed to identify a robust lipid metabolism‐related signature associated with the HCC …

Lipid metabolism in oncology: why it matters, how to research, and how to treat

Y Matsushita, H Nakagawa, K Koike - Cancers, 2021 - mdpi.com
Simple Summary Metabolic reprogramming is gaining attentions as a hallmark of cancers.
However, lipid metabolism has been difficult to analyze due to technical problems. In recent …

Spatially resolved multi-omics highlights cell-specific metabolic remodeling and interactions in gastric cancer

C Sun, A Wang, Y Zhou, P Chen, X Wang… - Nature …, 2023 - nature.com
Mapping tumor metabolic remodeling and their spatial crosstalk with surrounding non-tumor
cells can fundamentally improve our understanding of tumor biology, facilitates the …

Single-cell transcriptome analysis reveals heterogeneity and convergence of the tumor microenvironment in colorectal cancer

S Xie, Y Cai, D Chen, Y Xiang, W Cai, J Mao… - Frontiers in …, 2023 - frontiersin.org
Introduction Colorectal cancer (CRC) ranks second for mortality and third for morbidity
among the most commonly diagnosed cancers worldwide. We aimed to investigate the …

Lipid metabolism at the nexus of diet and tumor microenvironment

B Peck, A Schulze - Trends in cancer, 2019 - cell.com
Obesity is a leading contributing factor to cancer development worldwide. Epidemiological
evidence suggests that diet affects cancer risk and also substantially alters therapeutic …

Expression of lipid-metabolism genes is correlated with immune microenvironment and predicts prognosis in osteosarcoma

H Qian, T Lei, Y Hu, P Lei - Frontiers in cell and developmental …, 2021 - frontiersin.org
Objectives Osteosarcoma was the most popular primary malignant tumor in children and
adolescent, and the 5-year survival of osteosarcoma patients gained no substantial …