AIM: To investigate the in vivo hepatoprotective effects and mechanisms of Gentiana
manshurica Kitagawa (GM) in acetaminophen (APAP)-induced liver injury in mice …

Background Inappropriate use of acetaminophen (APAP) can lead to morbidity and mortality
secondary to hepatic necrosis. Aims We evaluated the beneficial effect and molecular …

Background: Frequent overdosing of acetaminophen (APAP) has become the major cause
of acute liver injury (ALI). The present study aimed to evaluate the potential hepatoprotective …

Background Similar to the leaves of P. Quinquefolius, American ginseng berry (AGB) is
another important part of P. Quinquefolius with alternative therapeutic potential. The liver …

Many plant-derived natural products have the potential to be hepatoprotective and therefore
can be used to treat acute and chronic liver diseases. The challenge is to identify the most …

Thymoquinone (TQ) is a main aromatic component of Nigella sativa L. seeds or Agastache
rugosa (Fisch. & CA Mey.) Kuntze. The protective mechanism of TQ against acute liver injury …

Amygdalin is a natural compound from Bitter Apricot Seed which is reported to have anti-
inflammatory activity. Acetaminophen (APAP) resulted in drug-induced liver injury is the …

Acetaminophen (APAP) overdose accounts for the majority of acute liver failure cases, and
oxidative stress plays a key role in its toxic effects. Esculentoside A (EsA) has anti-oxidant …

APAP is one of the most commonly used antipyretic and pain medications, but excessive
use can cause liver toxicity and damage. 3, 4-dihydroxyphenylethyl alcohol glycoside (DAG) …

Gastrodin is a major active phenolic glycoside extract from Gastrodia elata, an important
herb used in traditional medicine. Previous research has reported that gastrodin possesses …