Accumulation of β-amyloid (Aβ) and resultant inflammation are critical pathological features
of Alzheimer disease (AD). Microglia, a primary immune cell in brain, ingests and degrades …

Dysfunctional autophagy has been implicated in the pathogenesis of Alzheimer's disease
(AD). Previous evidence suggested disruptions of multiple stages of the autophagy …

Autophagy is a proposed route of amyloid-β (Aβ) clearance by microglia that is halted in
Alzheimer's Disease (AD), though mechanisms underlying this dysfunction remain elusive …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the
presence of misfolded proteins, amyloid-β (Aβ) aggregates, and neuroinflammation in the …

Background Autophagy is a major pathway of protein and organelle degradation in the
lysosome. Autophagy exists at basal constitutive level and can be induced as a defense …

Alzheimer's disease is characterized not only by extracellular amyloid plaques and
neurofibrillary tangles, but also by microglia‐mediated neuroinflammation. Recently …

Microglia have multiple functions in regulating homeostasis in the central nervous system
(CNS), and microglial inflammation is thought to play a role in the etiology of the …

Autophagy is emerging as a core regulator of Central Nervous System (CNS) aging and
neurodegeneration. In the brain, it has mostly been studied in neurons, where the delivery of …

Innate immunity and inflammatory response plays an important role in the pathogenesis of
Alzheimer's disease (AD). As the major resident immune cells in the brain, microglial cells …

Neuroinflammation is considered as a detrimental factor in neurodegenerative diseases,
including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD) …