Metformin plays an anti-proliferative role in tumor cells in many types of cancer. However,
the correlation between metformin and sensitivity to chemotherapeutic agents in …

The Yes‐associated protein (YAP)/Hippo pathway has been implicated in tissue
development, regeneration, and tumorigenesis. However, its role in cholangiocarcinoma …

hydroxytryptamine (5-HT, serotonin) and Yes-associated protein (Yap), which act as a
mitogen and an oncogene, respectively, play an important role in tumors. Here, we …

Abstract In China, Trametes robiniophila Murr (Huaier), a traditional Chinese herbal
medicine, has been widely used in adjuvant therapies of hepatocellular carcinoma (HCC) …

Tumor chemoresistance is often a major cause for the failure of chemotherapy. The
resistance of hepatocellular carcinoma (HCC) cells to sorafenib significantly limits its …

Hepatocellular carcinoma (HCC) is the third leading cause of liver-related death. Lipophilic
statins have been associated with a decrease in HCC incidence, raising the possibility of …

Bile acids (BAs) was critical in the initiation and progression of various tumors. However,
their prognostic significance in pancreatic cancer was still illusive. In the present study, the …

Elevated bile acid levels increase hepatocellular carcinoma by unknown mechanisms. Here,
we show that mice with a severe defect in bile acid homeostasis due to the loss of the …

The expression of estrogen receptor alpha (ERα, encoded by ESR1) has been shown to be
associated with the prognostic outcomes of patients in various cancers; however, its …

The oncoprotein Yes-associated protein (YAP) in Hippo pathway plays crucial roles in the
development of cancer. However, the mechanism of YAP regulation in cancer remains …