[HTML][HTML] Anti-cancer activity of verteporfin in cholangiocarcinoma
Simple Summary Cholangiocarcinoma (CCA) is a highly lethal malignancy, and its
prognosis is poor. There are unmet needs to develop effective therapies. The …
prognosis is poor. There are unmet needs to develop effective therapies. The …
[HTML][HTML] FXR induces SOCS3 and suppresses hepatocellular carcinoma
F Guo, Z Xu, Y Zhang, P Jiang, G Huang, S Chen… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Suppressor of cytokine signaling 3 (SOCS3) is regarded as a vital repressor in the liver
carcinogenesis mainly by inhibiting signal transducer and activator of transcription 3 …
carcinogenesis mainly by inhibiting signal transducer and activator of transcription 3 …
[PDF][PDF] Yes‐associated protein 1 and transcriptional coactivator with PDZ‐binding motif activate the mammalian target of rapamycin complex 1 pathway by regulating …
Metabolic activation is a common feature of many cancer cells and is frequently associated
with the clinical outcomes of various cancers, including hepatocellular carcinoma. Thus …
with the clinical outcomes of various cancers, including hepatocellular carcinoma. Thus …
[HTML][HTML] Atorvastatin augments gemcitabine-mediated anti-cancer effects by inhibiting yes-associated protein in human cholangiocarcinoma cells
K Kitagawa, K Moriya, K Kaji, S Saikawa… - International journal of …, 2020 - mdpi.com
Cholangiocarcinoma (CCA) is associated with high mortality rates because of its resistance
to conventional gemcitabine-based chemotherapy. Hydroxy-methyl-glutaryl-coenzyme A …
to conventional gemcitabine-based chemotherapy. Hydroxy-methyl-glutaryl-coenzyme A …
Dihydroartemisinin increased the abundance of Akkermansia muciniphila by YAP1 depression that sensitizes hepatocellular carcinoma to anti-PD-1 immunotherapy
Z Zhang, X Shi, J Ji, Y Guo, Q Peng, L Hao, Y Xue… - Frontiers of …, 2023 - Springer
The effect of anti-programmed cell death 1 (anti-PD-1) immunotherapy is limited in patients
with hepatocellular carcinoma (HCC). Yes-associated protein 1 (YAP1) expression …
with hepatocellular carcinoma (HCC). Yes-associated protein 1 (YAP1) expression …
[HTML][HTML] miR-590-5p suppresses hepatocellular carcinoma chemoresistance by targeting YAP1 expression
M Chen, L Wu, J Tu, Z Zhao, X Fan, J Mao, Q Weng… - …, 2018 - thelancet.com
Background Resistance to chemotherapeutic treatment is a common phenomenon in
cancers, especially in hepatocellular carcinoma (HCC). The Hippo signaling pathway has …
cancers, especially in hepatocellular carcinoma (HCC). The Hippo signaling pathway has …
Mice with hepatocyte-specific FXR deficiency are resistant to spontaneous but susceptible to cholic acid-induced hepatocarcinogenesis
B Kong, Y Zhu, G Li, JA Williams… - American Journal …, 2016 - journals.physiology.org
Farnesoid X receptor (FXR) belongs to the nuclear receptor superfamily with its endogenous
ligands bile acids. Mice with whole body FXR deficiency develop liver tumors …
ligands bile acids. Mice with whole body FXR deficiency develop liver tumors …
[HTML][HTML] YAP is a critical oncogene in human cholangiocarcinoma
T Pei, Y Li, J Wang, H Wang, Y Liang, H Shi, B Sun… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Abstract Yes-associated protein (YAP), a transcriptional co-activator, has important
regulatory roles in cell signaling and is dysregulated in a number of cancers. However, the …
regulatory roles in cell signaling and is dysregulated in a number of cancers. However, the …
[HTML][HTML] Reactive oxygen species-induced activation of Yes-associated protein-1 through the c-Myc pathway is a therapeutic target in hepatocellular carcinoma
Y Cho, MJ Park, K Kim, SW Kim, W Kim… - World Journal of …, 2020 - ncbi.nlm.nih.gov
BACKGROUND The Hippo signaling pathway regulates organ size by regulating cell
proliferation and apoptosis with terminal effectors including Yes-associated protein-1 (YAP …
proliferation and apoptosis with terminal effectors including Yes-associated protein-1 (YAP …
Regulatory factor X5 promotes hepatocellular carcinoma progression by transactivating tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein …
DB Chen, YJ Zhao, XY Wang, WJ Liao… - Chinese medical …, 2019 - mednexus.org
Background: Our previous studies have shown that regulatory factor X5 (RFX5), a classical
transcription regulator of MHCII genes, was obviously overexpressed in hepatocellular …
transcription regulator of MHCII genes, was obviously overexpressed in hepatocellular …