Diabetes and obesity are associated with non-alcoholic steatohepatitis and an increased
incidence of hepatocellular carcinoma (HCC). TAZ and YAP are equivalently placed …

Farnesoid X receptor (FXR) is a nuclear receptor known to play protective roles in anti-
hepatocarcinogenesis and regulation of the basal metabolism of glucose, lipids, and bile …

Hepatocellular carcinoma (HCC) is one of the most aggressive malignancies worldwide and
is highly resistant to chemotherapy. Yes-associated protein (YAP) is the downstream effector …

Cholestasis causes the intrahepatic accumulation of bile acids leading to hepatobiliary
injury. Recently obeticholic acid, a farnesoid X receptor (FXR) agonist, was FDA-approved to …

Orthodenticle homeobox (OTX1) is reported to be involved in numerous cancers, but the
expression level and molecular function of OTX1 in gallbladder cancer (GBC) remain …

YAP-TEAD complex plays an important role in tumorigenesis. 5-HT is proved to upregulate
YAP expression by our previous study and VGLL4 is found to compete with YAP for binding …

RNA binding motif protein 3 (RBM3) has been shown to be upregulated in several types of
human tumors. Using tissue microarrays and immunohistochemistry, we showed here that …

Background: Hepatocellular carcinoma (HCC) is the most common form of liver cancer and
is generally caused by viral infections or consumption of mutagens, such as alcohol. While …

Dihydroartemisinin (DHA), a semi-synthetic derivative of artemisinin isolated from the
traditional Chinese herb Artemisia annua L., has been shown to exhibit inhibitory effects on …

Recent clinical and experimental evidences strongly acclaim Yes-associated protein (Yap),
a key oncogenic driver in liver carcinogenesis, as a therapeutic target. Of the known multiple …