Human telomerase reverse transcriptase (hTERT) is highly expressed in many tumors and is
essential for tumorigenesis and metastasis in multiple cancers. However, the molecular …

Metabolic activation is a common feature of many cancer cells and is frequently associated
with the clinical outcomes of various cancers, including hepatocellular carcinoma (HCC) …

Bile acids, which are synthesized from cholesterol in the hepatocytes of the liver, are
amphipathic molecules with a steroid backbone. Studies have shown that bile acid exhibits …

Emerging studies have suggested that the Hippo pathway is involved in the tumorigenesis of
hepatocellular carcinoma (HCC). However, the key regulator of the Hippo pathway in liver …

Abstract Hepatitis B virus (HBV) X protein (HBx) is implicated in the development of
hepatocellular carcinoma (HCC). Yes-associated protein 1 (YAP) is an important proto …

The yes-associated protein (YAP) transcription co-activator has been reported either as an
oncogene candidate or a tumor suppressor. Liver tissue chips revealed that about 51.4 …

Background & Aims Long non-coding RNA Hotair has been considered as a pro-oncogene
in multiple cancers. Although there is emerging evidence that reveals its biological function …

Great progress has been achieved in the study of Hippo signaling in regulating
tumorigenesis; however, the downstream molecular events that mediate this process have …

Atorvastatin is a competitive inhibitor of β‑hydroxy β‑methylglutaryl‑CoA reductase, which is
involved in anticancer effects in numerous types of cancer, including in human liver cancer …

Cholangiocarcinoma (CCA) is a destructive malignancy with limited responsiveness to
conventional chemotherapy. Although angiotensin receptor blockers (ARBs) have gained …