Background & Aims Hypoxia and hypoxia-inducible factors (HIFs) are involved in chronic
liver disease progression. We previously showed that hepatocyte HIF-2α activation …

Background and Aims HCC is the most predominant type of liver cancer affecting 800,000
people globally each year. Various small‐molecule compounds targeting diverse oncogenic …

Tumor metastasis is the leading cause of death in cancer patients. Identifying metastatic
biomarkers in tumor cells would help cancer diagnoses and the development of therapeutic …

Abstract The MST/YAP (mammalian Ste20-like kinase/Yes-associated protein 2) pathway
plays an important role in hepatocellular carcinoma (HCC). Although post-translational …

Hepatitis B virus X protein (HBx) plays critical roles in the development of hepatocellular
carcinogenesis (HCC). Yes‐associated protein (YAP), a downstream effector of the Hippo …

FXR agonistic activity screening was conducted based on natural product resources
containing 38 structurally diverse sesquiterpenoids isolated from Xylopia vielana. Among …

Background/Aims: Intrahepatic cholangiocarcinoma (ICC) is a complicated condition, with
difficult diagnosis and poor prognosis. The expression and clinical significance of the …

Simple Summary Activation of YAP/TAZ (mediators of Hippo signaling) is associated with the
development of liver cancer. The expression level of YAP is known to relate to …

Background and Aims Constitutive androstane receptor (CAR) agonists, such as 1, 4‐bis [2‐
(3, 5‐dichloropyridyloxy)] benzene (TCPOBOP), are known to cause robust hepatocyte …

Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor associated with
tumor initiation and progression. AhR expression is significantly increased in gastric cancer …