Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells
Y Ding, X Chen, C Liu, W Ge, Q Wang, X Hao… - Journal of hematology & …, 2021 - Springer
Background TNBC is the most aggressive breast cancer with higher recurrence and
mortality rate than other types of breast cancer. There is an urgent need for identification of …
mortality rate than other types of breast cancer. There is an urgent need for identification of …
Role of GPX4-mediated ferroptosis in the sensitivity of triple negative breast cancer cells to gefitinib
X Song, X Wang, Z Liu, Z Yu - Frontiers in oncology, 2020 - frontiersin.org
Gefitinib resistance in triple negative breast cancer (TNBC) is a growing important concern.
Glutathione peroxidase 4 (GPX4) is a main regulator of ferroptosis, which is pivotal for TNBC …
Glutathione peroxidase 4 (GPX4) is a main regulator of ferroptosis, which is pivotal for TNBC …
Dual degradation mechanism of GPX4 degrader in induction of ferroptosis exerting anti-resistant tumor effect
C Wang, C Zheng, H Wang, S Shui, H Jin, G Liu… - European Journal of …, 2023 - Elsevier
Abstract Targeting Glutathione peroxidase 4 (GPX4) has become a promising strategy for
drug-resistant cancer therapy via ferroptosis induction. It was found that the GPX4 inhibitors …
drug-resistant cancer therapy via ferroptosis induction. It was found that the GPX4 inhibitors …
Inhibition of tumor propellant glutathione peroxidase 4 induces ferroptosis in cancer cells and enhances anticancer effect of cisplatin
X Zhang, S Sui, L Wang, H Li, L Zhang… - Journal of cellular …, 2020 - Wiley Online Library
Abstract Glutathione peroxidase 4 (GPX4) has been confirmed to inhibit ferroptosis in cancer
cells, however, whether GPX4 serves as an oncogene is not clear. In this study, the …
cells, however, whether GPX4 serves as an oncogene is not clear. In this study, the …
Identification of a small molecule that enhances ferroptosis via inhibition of ferroptosis suppressor protein 1 (FSP1)
H Yoshioka, T Kawamura, M Muroi… - ACS Chemical …, 2022 - ACS Publications
Glutathione peroxidase 4 (GPX4) is an intracellular enzyme that oxidizes glutathione while
reducing lipid peroxides and is a promising target for cancer therapy. To date, several GPX4 …
reducing lipid peroxides and is a promising target for cancer therapy. To date, several GPX4 …
Prospects for anti-tumor mechanism and potential clinical application based on glutathione peroxidase 4 mediated ferroptosis
M Chen, Z Shi, Y Sun, H Ning, X Gu… - International Journal of …, 2023 - mdpi.com
Ferroptosis, characterized by excessive iron accumulation and lipid peroxidation, is a novel
form of iron-dependent cell death, which is morphologically, genetically, and biochemically …
form of iron-dependent cell death, which is morphologically, genetically, and biochemically …
Discovery of ML210-Based glutathione peroxidase 4 (GPX4) degrader inducing ferroptosis of human cancer cells
H Wang, C Wang, B Li, C Zheng, G Liu, Z Liu… - European Journal of …, 2023 - Elsevier
Ferroptosis is an iron-dependent cell death caused by the accumulation of lipid
peroxidation. The glutathione peroxidase 4 (GPX4) is an antioxidative enzyme and a major …
peroxidation. The glutathione peroxidase 4 (GPX4) is an antioxidative enzyme and a major …
Discovery of novel potent covalent glutathione peroxidase 4 inhibitors as highly selective ferroptosis inducers for the treatment of triple-negative breast cancer
T Chen, J Leng, J Tan, Y Zhao, S Xie… - Journal of Medicinal …, 2023 - ACS Publications
Glutathione peroxidase 4 (GPX4) is a promising target to induce ferroptosis for the treatment
of triple-negative breast cancer (TNBC). We designed and synthesized a novel series of …
of triple-negative breast cancer (TNBC). We designed and synthesized a novel series of …
Targeting GPX4 in human cancer: Implications of ferroptosis induction for tackling cancer resilience
J Lee, JL Roh - Cancer Letters, 2023 - Elsevier
Cancer metabolic alterations have been emphasized to protect cancer cells from cell death.
The metabolic reprogramming toward a mesenchymal state makes cancer cells resistant to …
The metabolic reprogramming toward a mesenchymal state makes cancer cells resistant to …
Bufotalin induces ferroptosis in non-small cell lung cancer cells by facilitating the ubiquitination and degradation of GPX4
W Zhang, B Jiang, Y Liu, L Xu, M Wan - Free Radical Biology and Medicine, 2022 - Elsevier
Ferroptosis is a new form of regulated cell death that is dependent on iron-and lipid reactive
oxygen species. Emerging evidence indicate that induction of ferroptosis could inhibit the …
oxygen species. Emerging evidence indicate that induction of ferroptosis could inhibit the …