Background: An intricate network of reciprocal interactions between adipose tissue and
immune system have been largely demonstrated, leading to the well-accepted concept of …

The complement system has been implicated in obesity, fatty liver, diabetes and
cardiovascular disease (CVD). Complement factors are produced in adipose tissue and …

OBJECTIVE: To investigate the role of low-grade inflammation and insulin resistance
(HOMA2-IR) in adiposity-related increases in serum complement factor 3 (C3). Although C3 …

Introduction: Increased systemic inflammation plays a significant role in the development of
adult cardiometabolic diseases such as insulin resistance, dyslipidemia, atherosclerosis …

Introduction Obesity is frequently characterized by chronic inflammation and insulin
resistance (IR). Obesity-associated inflammation is responsible for the complement system …

Background In several reports, C3 and C4 have been linked to diabetes and cardiovascular
disease (CVD). Here, we investigate this link and the degree of C3 activation in elderly …

Eur J Clin Invest 2011; 41 (4): 372–379 Abstract Background Complement C3, a central
component of the innate immune system is increased in subjects with obesity and type 2 …

As the common factor linking adipose tissue to the metabolic context of obesity, insulin
resistance and atherosclerosis are associated with a low-grade chronic inflammatory status …

Background and aims To evaluate if complement C3 is associated with insulin secretion, as
suggested by recent in vitro studies, independently of confounders including adiposity …

Background The central component of the complement system, C3, is associated with
obesity, metabolic syndrome and cardiovascular disease however the underlying reasons …