Exploring the effect of a series of flavonoids on tyrosinase using integrated enzyme kinetics, multispectroscopic, and molecular modelling analyses

J Chen, Z Zhang, H Li, H Tang - International Journal of Biological …, 2023 - Elsevier
The control of food browning can be achieved by inhibiting tyrosinase (TY) activity, but
current studies on the interaction of flavonoids as potent inhibitors with TY are inadequate …

Five individual polyphenols as tyrosinase inhibitors: Inhibitory activity, synergistic effect, action mechanism, and molecular docking

Q Yu, L Fan, Z Duan - Food chemistry, 2019 - Elsevier
Polyphenols can inhibit the enzymatic browning in food, but their indistinct synergistic effect
and conformational change have limited their applications. In this paper, the mixture of …

Understanding the combined effect and inhibition mechanism of 4-hydroxycinnamic acid and ferulic acid as tyrosinase inhibitors

Q Yu, L Fan - Food Chemistry, 2021 - Elsevier
The development of tyrosinase inhibitors to prevent the enzymatic browning have become a
research hotspot in food industry. 4-Hydroxycinnamic acid (CA) and ferulic acid (FA) are …

Inhibition characteristics and mechanism of tyrosinase using five citrus flavonoids: A spectroscopic and molecular dynamics simulation study

W Li, H Tian, F Guo, Y Wu - Journal of Food Biochemistry, 2022 - Wiley Online Library
This work presents a comparative analysis of the tyrosinase inhibitory effects of five citrus
flavonoids, namely hesperetin, hesperidin, neohesperidin, naringenin and naringin. Visbile …

[HTML][HTML] Understanding the inhibitory mechanism of tea polyphenols against tyrosinase using fluorescence spectroscopy, cyclic voltammetry, oximetry, and molecular …

H Tang, F Cui, H Li, Q Huang, Y Li - RSC advances, 2018 - pubs.rsc.org
Inhibiting the activity of tyrosinase is a very effective and safe way to prevent enzymatic
browning in food and to resist pests in agriculture. Tea polyphenols (TPs), regarded as safe …

Structural and inhibitory effects of fulvic and humic acids against tyrosinase

N Taherkhani, A Hekmat, H Piri… - Journal of Food …, 2022 - Wiley Online Library
Inhibition of tyrosinase activity can control fruit browning and preserve the flavor and
nutritional value of food. The impacts of fulvic acid (FA) and humic acid (HA) on tyrosinase …

[HTML][HTML] Promotion effects of flavonoids on browning induced by enzymatic oxidation of tyrosinase: structure–activity relationship

Y Lu, Y Xu, MT Song, LL Qian, XL Liu, RY Gao… - RSC …, 2021 - pubs.rsc.org
Tyrosinase, widely distributed in nature, is a copper-containing polyphenol oxidase involved
in the formation of melanin. Flavonoids are most often considered as tyrosinase inhibitors …

Evaluation of inhibitory effects of some novel phenolic derivatives on the mushroom tyrosinase activity: Insights from spectroscopic analyses, molecular docking and in …

A Mahdavi, N Mohammadsadeghi, F Mohammadi… - Food Chemistry, 2022 - Elsevier
Tyrosinase plays determinant role in enzymatic browning of vegetables and fresh-cut fruits.
Development of new tyrosinase inhibitors is of great concern in food and agriculture. To …

Inhibition of albendazole and 2‐(2‐aminophenyl)‐1H‐benzimidazole against tyrosinase: mechanism, structure–activity relationship, and anti‐browning effect

Y Wen, Y Zhang, X Zhang, L Wang… - Journal of the …, 2023 - Wiley Online Library
BACKGROUND Tyrosinase is the key enzyme involved in enzymatic browning of plant‐
derived foods. Inhibition of tyrosinase activity contributes to the control of food browning …

[HTML][HTML] Determination of tyrosinase-cyanidin-3-O-glucoside and (−/+)-catechin binding modes reveal mechanistic differences in tyrosinase inhibition

KE Lee, S Bharadwaj, AK Sahoo, U Yadava… - Scientific Reports, 2021 - nature.com
Tyrosinase, exquisitely catalyzes the phenolic compounds into brown or black pigment,
inhibition is used as a treatment for dermatological or neurodegenerative disorders. Natural …