Platycodin D relieves rheumatoid arthritis by promoting apoptosis of mitochondria to inhibit activation of hedgehog pathway
P Li, Y Huang, J Wang, J Zeng, L Li - Autoimmunity, 2023 - Taylor & Francis
Rheumatoid arthritis (RA) displays very similar characteristics to those of tumor cells,
platycodin D (PD) is a triterpenoid saponin abundant in Platycodon grandiflorum (PG), plays …
platycodin D (PD) is a triterpenoid saponin abundant in Platycodon grandiflorum (PG), plays …
Effects of platycodin D on IL-1β-induced inflammatory response in human osteoarthritis chondrocytes
Y Qu, L Zhou, C Wang - International Immunopharmacology, 2016 - Elsevier
Platycodin D (PYD), a major saponin derived and isolated from the roots of Platycodon
grandiflorum, has been reported to have anti-inflammatory and anti-tumor effects. The …
grandiflorum, has been reported to have anti-inflammatory and anti-tumor effects. The …
Gossypol ameliorates the IL-1β-induced apoptosis and inflammation in chondrocytes by suppressing the activation of TLR4/MyD88/NF-κB pathway via …
S Li, F Xie, K Shi, J Wang, Y Cao, Y Li - Tissue and Cell, 2021 - Elsevier
The effects of anti-inflammatory drug gossypol on osteoarthritis (OA) treatment were
discussed in this paper. After identified using toluidine blue and immunofluorescence …
discussed in this paper. After identified using toluidine blue and immunofluorescence …
[HTML][HTML] The molecular mechanism of treating osteoarthritis with dipsacus saponins by inhibiting chondrocyte apoptosis
XR Li, J Li, Q Ren, S Sun - … and Therapeutic Medicine, 2017 - spandidos-publications.com
The present study aimed to determine the molecular mechanism of treating osteoarthritis
with dipsacus saponins by inhibiting the apoptosis of chondrocytes. A total of 30 New …
with dipsacus saponins by inhibiting the apoptosis of chondrocytes. A total of 30 New …
[HTML][HTML] GSK-3β inhibition alleviates arthritis pain via reducing spinal mitochondrial reactive oxygen species level and inflammation
HY Yang, X Sun, SQ Zhen, LZ Yu, JQ Ding, L Liu… - PLoS …, 2023 - journals.plos.org
Pain is the main symptom of osteoarthritis, which severely reduces the patients' quality of
life. Stimulated neuroinflammation and elevated mitochondrial oxidative stress are …
life. Stimulated neuroinflammation and elevated mitochondrial oxidative stress are …
[HTML][HTML] Saikosaponin D Inhibited IL-1β Induced ATDC 5 Chondrocytes Apoptosis In Vitro and Delayed Articular Cartilage Degeneration in OA Model Mice In Vivo
X Wu, K Zhao, X Fang, F Lu, P Cheng… - Frontiers in …, 2022 - frontiersin.org
Osteoarthritis (OA) is the most common joint disease in the elderly, characterized by
cartilage degradation and proliferation of subchondral bone. The pathogenesis of OA …
cartilage degradation and proliferation of subchondral bone. The pathogenesis of OA …
[HTML][HTML] Chondro-Protective Effects of Shikimic Acid on Osteoarthritis via Restoring Impaired Autophagy and Suppressing the MAPK/NF-κB Signaling Pathway
H You, R Zhang, L Wang, Q Pan, Z Mao… - Frontiers in …, 2021 - frontiersin.org
Osteoarthritis (OA) is a major cause of cartilage pain and limited mobility in middle-aged and
elderly individuals. The degeneration of cartilage induced by inflammation and cartilage …
elderly individuals. The degeneration of cartilage induced by inflammation and cartilage …
Platycodin D inhibits proliferation, migration and induces chemosensitization through inactivation of the NF‐κB and JAK 2/STAT 3 pathways in multiple myeloma cells
D Wu, W Zhang, Y Chen, H Ma… - Clinical and Experimental …, 2019 - Wiley Online Library
Multiple myeloma (MM) is a malignancy characterized by the proliferation of malignant
plasma cells. Platycodin D (PLD) is a triterpenoid saponin that exerts anti‐tumour activity …
plasma cells. Platycodin D (PLD) is a triterpenoid saponin that exerts anti‐tumour activity …
Anti-rheumatoid arthritis effects of total saponins from Rhizoma Panacis Majoris on adjuvant-induced arthritis in rats and rheumatoid arthritis fibroblast-like …
M Ren, K Ma, X Pang, Y Liu, Z Song, R Zhou, Z Tang - Phytomedicine, 2023 - Elsevier
Abstract Background Total saponins from Rhizoma Panacis Majoris (RPMTG) showed
significant antitumour activity in our previous studies. Rheumatoid arthritis fibroblast-like …
significant antitumour activity in our previous studies. Rheumatoid arthritis fibroblast-like …
[HTML][HTML] Panax quinquefolium saponin inhibits endoplasmic reticulum stress-induced apoptosis and the associated inflammatory response in chondrocytes and …
JJ Xie, J Chen, SK Guo, YT Gu, YZ Yan, WJ Guo… - Biomedicine & …, 2018 - Elsevier
Treatments for osteoarthritis (OA) seek to restore chondrocyte function and inhibit cell
apoptosis. Panax quinquefolium saponin (PQS) is the major active ingredient of Radix …
apoptosis. Panax quinquefolium saponin (PQS) is the major active ingredient of Radix …